104249

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 330325..330865 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag N16961_RS15570 Protein ID WP_000277238.1
Coordinates 330325..330594 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag N16961_RS15575 Protein ID WP_001258569.1
Coordinates 330587..330865 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N16961_RS15500 325329..325571 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
N16961_RS15505 325815..326201 + 387 WP_001015867.1 NUDIX hydrolase -
N16961_RS15510 326258..326371 + 114 WP_001900214.1 hypothetical protein -
N16961_RS15515 326320..326601 + 282 WP_001894429.1 DUF1289 domain-containing protein -
N16961_RS15530 326859..327395 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
N16961_RS15535 327532..328047 + 516 WP_001201509.1 lipocalin family protein -
N16961_RS15540 328197..328694 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
N16961_RS15545 328691..328963 - 273 WP_000246253.1 DUF1778 domain-containing protein -
N16961_RS15550 329356..329481 + 126 WP_001900195.1 DUF645 family protein -
N16961_RS15555 329497..329535 + 39 WP_106019118.1 hypothetical protein -
N16961_RS15565 329731..330177 + 447 WP_000006157.1 hypothetical protein -
N16961_RS15570 330325..330594 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
N16961_RS15575 330587..330865 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N16961_RS15585 331151..331429 + 279 WP_001921601.1 DUF3709 domain-containing protein -
N16961_RS15590 331681..331887 + 207 Protein_294 DUF3709 domain-containing protein -
N16961_RS15595 332087..332188 + 102 WP_001921603.1 hypothetical protein -
N16961_RS15600 332178..332564 + 387 WP_000703163.1 VOC family protein -
N16961_RS15605 332759..333010 + 252 WP_001890111.1 TIGR03643 family protein -
N16961_RS15610 332983..333132 + 150 WP_071908333.1 DUF3265 domain-containing protein -
N16961_RS15615 333224..333466 + 243 WP_000107461.1 hypothetical protein -
N16961_RS15620 333718..333996 + 279 WP_000280324.1 DUF3709 domain-containing protein -
N16961_RS19805 334371..334514 + 144 Protein_301 DUF645 family protein -
N16961_RS19810 334568..334606 + 39 WP_082798268.1 hypothetical protein -
N16961_RS15635 334818..335285 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306977..438073 131096
inside Integron - - 312057..437697 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T104249 WP_000277238.1 NZ_CP028828:c330594-330325 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T104249 NZ_CP028828:c330594-330325 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT104249 WP_001258569.1 NZ_CP028828:c330865-330587 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT104249 NZ_CP028828:c330865-330587 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References