Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 420524..421139 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag DG176_RS16450 Protein ID WP_001162670.1
Coordinates 420852..421139 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DG176_RS16445 Protein ID WP_001232701.1
Coordinates 420524..420841 (-) Length 106 a.a.

Genomic Context

DG176_RS16480DG176_RS16485DG176_RS16395DG176_RS16400DG176_RS16405DG176_RS16410DG176_RS16415DG176_RS16420DG176_RS19810DG176_RS19815DG176_RS19820DG176_RS16445DG176_RS16450DG176_RS16455DG176_RS16460DG176_RS16465DG176_RS16470DG176_RS16475DG176_RS19825
Location: 424636..424878 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 424897..425214 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 415933..416448 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 416585..417061 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 417089..417199 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 417196..418125 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 418245..418691 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 418844..419848 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 420061..420099 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 420115..420240 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 420417..420527 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 420524..420841 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 420852..421139 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 421406..421586 (181 bp)
Type: Others
Protein ID: Protein_392
Location: 422011..422244 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 422647..422865 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 423175..423828 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 423885..424394 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 425408..425503 (96 bp)
Type: Others
Protein ID: WP_001907607.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG176_RS16395415933..416448-516WP_001201528.1lipocalin family protein-
DG176_RS16400416585..417061-477WP_001047180.1GNAT family N-acetyltransferase-
DG176_RS16405417089..417199-111WP_071917832.1DUF3265 domain-containing protein-
DG176_RS16410417196..418125-930WP_000335802.1hypothetical protein-
DG176_RS16415418245..418691-447WP_000128977.1hypothetical protein-
DG176_RS16420418844..419848-1005WP_000964925.1LD-carboxypeptidase-
DG176_RS19810420061..420099-39WP_106019119.1hypothetical protein-
DG176_RS19815420115..420240-126WP_001944767.1DUF645 family protein-
DG176_RS19820420417..420527-111WP_134814058.1DUF3265 domain-containing protein-
DG176_RS16445420524..420841-318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
DG176_RS16450420852..421139-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG176_RS16455421406..421586-181Protein_392DUF645 family protein-
DG176_RS16460422011..422244-234WP_032482776.1DUF3709 domain-containing protein-
DG176_RS16465422647..422865-219WP_001917086.1DUF3709 domain-containing protein-
DG176_RS16470423175..423828-654WP_000226874.1hypothetical protein-
DG176_RS16475423885..424394-510WP_000405987.1GNAT family N-acetyltransferase-
DG176_RS16480424636..424878+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG176_RS16485424897..425214+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
DG176_RS19825425408..425503-96WP_001907607.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-379325..47629796972
insideIntegroncatB9-379701..46950989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T294378 WP_001162670.1 NZ_LT992489:c421139-420852 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT294378 WP_001232701.1 NZ_LT992489:c420841-420524 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References