145818

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 426029..426576 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag GTF72_RS16100 Protein ID WP_000229317.1
Coordinates 426274..426576 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GTF72_RS16095 Protein ID WP_000861987.1
Coordinates 426029..426286 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF72_RS16050 421058..421513 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
GTF72_RS16055 421835..421987 + 153 WP_001884520.1 DUF645 family protein -
GTF72_RS16060 422189..422686 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF72_RS16065 422683..422955 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF72_RS16070 423186..423854 + 669 WP_000043871.1 hypothetical protein -
GTF72_RS16075 424006..424293 + 288 WP_000426470.1 hypothetical protein -
GTF72_RS16080 424434..424805 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GTF72_RS16085 424872..425297 + 426 WP_001882332.1 DUF1778 domain-containing protein -
GTF72_RS16090 425294..425827 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
GTF72_RS16095 426029..426286 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF72_RS16100 426274..426576 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF72_RS16105 426810..427727 + 918 WP_000186333.1 alpha/beta hydrolase -
GTF72_RS16110 427884..428273 + 390 WP_001081302.1 hypothetical protein -
GTF72_RS16115 428409..428618 + 210 Protein_471 GNAT family N-acetyltransferase -
GTF72_RS16120 428737..429174 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GTF72_RS16125 429238..429456 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
GTF72_RS16130 429631..430503 + 873 WP_000254716.1 DUF3800 domain-containing protein -
GTF72_RS16135 430653..431252 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GTF72_RS16140 431309..431413 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306905..436165 129260
inside Integron - - 311985..435789 123804
flank IS/Tn - - 428737..429174 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T145818 WP_000229317.1 NZ_CP047296:426274-426576 [Vibrio cholerae C6706]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T145818 NZ_CP062700:c3497044-3496889 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT145818 WP_000861987.1 NZ_CP047296:426029-426286 [Vibrio cholerae C6706]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT145818 NZ_CP062700:3497056-3497114 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References