Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 426029..426576 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag GTF72_RS16100 Protein ID WP_000229317.1
Coordinates 426274..426576 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GTF72_RS16095 Protein ID WP_000861987.1
Coordinates 426029..426286 (+) Length 86 a.a.

Genomic Context

GTF72_RS16050GTF72_RS16055GTF72_RS16070GTF72_RS16075GTF72_RS16080GTF72_RS16085GTF72_RS16090GTF72_RS16095GTF72_RS16100GTF72_RS16105GTF72_RS16110GTF72_RS16115GTF72_RS16120GTF72_RS16125GTF72_RS16130GTF72_RS16135GTF72_RS16140GTF72_RS16060GTF72_RS16065
Location: 421058..421513 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421835..421987 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 423186..423854 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 424006..424293 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 424434..424805 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424872..425297 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 425294..425827 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 426029..426286 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 426274..426576 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 426810..427727 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427884..428273 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428409..428618 (210 bp)
Type: Others
Protein ID: Protein_471
Location: 428737..429174 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 429238..429456 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429631..430503 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430653..431252 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 431309..431413 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 422189..422686 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422683..422955 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF72_RS16050421058..421513+456WP_001245327.1GNAT family N-acetyltransferase-
GTF72_RS16055421835..421987+153WP_001884520.1DUF645 family protein-
GTF72_RS16060422189..422686-498WP_000982260.1GNAT family N-acetyltransferase-
GTF72_RS16065422683..422955-273WP_000246253.1DUF1778 domain-containing protein-
GTF72_RS16070423186..423854+669WP_000043871.1hypothetical protein-
GTF72_RS16075424006..424293+288WP_000426470.1hypothetical protein-
GTF72_RS16080424434..424805+372WP_001164080.1nucleotide pyrophosphohydrolase-
GTF72_RS16085424872..425297+426WP_001882332.1DUF1778 domain-containing protein-
GTF72_RS16090425294..425827+534WP_000118351.1GNAT family N-acetyltransferase-
GTF72_RS16095426029..426286+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GTF72_RS16100426274..426576+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF72_RS16105426810..427727+918WP_000186333.1alpha/beta hydrolase-
GTF72_RS16110427884..428273+390WP_001081302.1hypothetical protein-
GTF72_RS16115428409..428618+210Protein_471GNAT family N-acetyltransferase-
GTF72_RS16120428737..429174+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
GTF72_RS16125429238..429456+219WP_071908318.1GNAT family N-acetyltransferase-
GTF72_RS16130429631..430503+873WP_000254716.1DUF3800 domain-containing protein-
GTF72_RS16135430653..431252+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
GTF72_RS16140431309..431413+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306905..436165129260
insideIntegron--311985..435789123804
flankIS/Tn--428737..429174437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T145818 WP_000229317.1 NZ_CP047296:426274-426576 [Vibrio cholerae C6706]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T145818 NZ_CP062700:c3497044-3496889 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT145818 WP_000861987.1 NZ_CP047296:426029-426286 [Vibrio cholerae C6706]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT145818 NZ_CP062700:3497056-3497114 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References