48153

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 373424..373952 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag IR04_RS01830 Protein ID WP_000221352.1
Coordinates 373424..373714 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag IR04_RS01835 Protein ID WP_000213183.1
Coordinates 373704..373952 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR04_RS20400 368694..368804 + 111 WP_134814058.1 DUF3265 domain-containing protein -
IR04_RS20405 368981..369106 + 126 WP_001944767.1 DUF645 family protein -
IR04_RS20410 369122..369160 + 39 WP_106019119.1 hypothetical protein -
IR04_RS01805 369373..370377 + 1005 WP_000964925.1 LD-carboxypeptidase -
IR04_RS01810 370530..370976 + 447 WP_000128977.1 hypothetical protein -
IR04_RS01815 371096..372025 + 930 WP_000335802.1 hypothetical protein -
IR04_RS19990 372022..372132 + 111 WP_071917832.1 DUF3265 domain-containing protein -
IR04_RS01820 372160..372636 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
IR04_RS01825 372773..373288 + 516 WP_001201528.1 lipocalin family protein -
IR04_RS01830 373424..373714 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IR04_RS01835 373704..373952 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IR04_RS01850 374523..375176 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
IR04_RS01855 375448..375873 + 426 WP_000415748.1 hypothetical protein -
IR04_RS01860 376081..376476 + 396 WP_000649527.1 DUF3465 domain-containing protein -
IR04_RS01865 376627..377157 + 531 WP_000415563.1 hypothetical protein -
IR04_RS01870 377295..377795 + 501 WP_000789723.1 hypothetical protein -
IR04_RS01875 377951..378349 + 399 WP_001882293.1 hypothetical protein -
IR04_RS01880 378449..378913 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..409892 105192
inside Integron - - 309780..409516 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T48153 WP_000221352.1 NZ_CP009041:c373714-373424 [Vibrio cholerae O1 biovar El Tor]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T48153 NZ_CP009041:c373714-373424 [Vibrio cholerae O1 biovar El Tor]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT48153 WP_000213183.1 NZ_CP009041:c373952-373704 [Vibrio cholerae O1 biovar El Tor]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT48153 NZ_CP009041:c373952-373704 [Vibrio cholerae O1 biovar El Tor]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References