87024

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 397477..398005 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag CSW01_RS16480 Protein ID WP_000221352.1
Coordinates 397477..397767 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag CSW01_RS16485 Protein ID WP_000213183.1
Coordinates 397757..398005 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSW01_RS19980 393034..393159 + 126 WP_001944767.1 DUF645 family protein -
CSW01_RS19985 393175..393213 + 39 WP_106019119.1 hypothetical protein -
CSW01_RS16450 393426..394430 + 1005 WP_000964925.1 LD-carboxypeptidase -
CSW01_RS16455 394583..395029 + 447 WP_000128977.1 hypothetical protein -
CSW01_RS16460 395149..396078 + 930 WP_000335802.1 hypothetical protein -
CSW01_RS16465 396075..396185 + 111 WP_071917832.1 DUF3265 domain-containing protein -
CSW01_RS16470 396213..396689 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
CSW01_RS16475 396826..397341 + 516 WP_001201528.1 lipocalin family protein -
CSW01_RS16480 397477..397767 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSW01_RS16485 397757..398005 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSW01_RS16505 398576..399229 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
CSW01_RS16510 399501..399926 + 426 WP_000415748.1 hypothetical protein -
CSW01_RS16515 400134..400529 + 396 WP_000649527.1 DUF3465 domain-containing protein -
CSW01_RS16520 400680..401210 + 531 WP_000415563.1 hypothetical protein -
CSW01_RS16525 401348..401848 + 501 WP_000789723.1 hypothetical protein -
CSW01_RS16535 402004..402401 + 398 Protein_419 hypothetical protein -
CSW01_RS16540 402501..402965 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304226..433944 129718
inside Integron - - 309306..433568 124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T87024 WP_000221352.1 NZ_CP024163:c397767-397477 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T87024 NZ_CP024163:c397767-397477 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT87024 WP_000213183.1 NZ_CP024163:c398005-397757 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT87024 NZ_CP024163:c398005-397757 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References