Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 122328..123094 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag HJ37_RS14820 Protein ID WP_000982260.1
Coordinates 122328..122825 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag HJ37_RS14825 Protein ID WP_000246253.1
Coordinates 122822..123094 (-) Length 91 a.a.

Genomic Context

HJ37_RS14780HJ37_RS14785HJ37_RS14790HJ37_RS20025HJ37_RS14795HJ37_RS14800HJ37_RS14805HJ37_RS14810HJ37_RS14815HJ37_RS14830HJ37_RS14835HJ37_RS14840HJ37_RS20245HJ37_RS14850HJ37_RS14855HJ37_RS14860HJ37_RS14865HJ37_RS14820HJ37_RS14825
Location: 118190..118462 (273 bp)
Type: Others
Protein ID: Protein_182
Location: 118633..119325 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 119325..119726 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 119696..119839 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 119914..120327 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 120541..120792 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 120782..121069 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 121197..121652 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 121974..122126 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 123325..123993 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 124145..124432 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 124573..124944 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 125011..125436 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 125433..125966 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 126168..126425 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 126413..126715 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 126949..127866 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 122328..122825 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 122822..123094 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HJ37_RS14780118190..118462+273Protein_182CatB-related O-acetyltransferase-
HJ37_RS14785118633..119325+693WP_001047169.1GNAT family N-acetyltransferase-
HJ37_RS14790119325..119726+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
HJ37_RS20025119696..119839+144WP_071908341.1DUF3265 domain-containing protein-
HJ37_RS14795119914..120327+414WP_000049417.1VOC family protein-
HJ37_RS14800120541..120792+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
HJ37_RS14805120782..121069+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
HJ37_RS14810121197..121652+456WP_001245327.1GNAT family N-acetyltransferase-
HJ37_RS14815121974..122126+153WP_001884520.1DUF645 family protein-
HJ37_RS14820122328..122825-498WP_000982260.1GNAT family N-acetyltransferaseToxin
HJ37_RS14825122822..123094-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
HJ37_RS14830123325..123993+669WP_000043871.1hypothetical protein-
HJ37_RS14835124145..124432+288WP_000426470.1hypothetical protein-
HJ37_RS14840124573..124944+372WP_001164080.1nucleotide pyrophosphohydrolase-
HJ37_RS20245125011..125436+426WP_001882332.1DUF1778 domain-containing protein-
HJ37_RS14850125433..125966+534WP_000118351.1GNAT family N-acetyltransferase-
HJ37_RS14855126168..126425+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
HJ37_RS14860126413..126715+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
HJ37_RS14865126949..127866+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31115..136304105189
insideIntegroncatB9-36195..13592899733
flankIS/Tn--117142..118122980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T25717 WP_000982260.1 NC_016446:c122825-122328 [Vibrio cholerae O1 str. 2010EL-1786]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T25717 NC_016446:c122825-122328 [Vibrio cholerae O1 str. 2010EL-1786]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT25717 WP_000246253.1 NC_016446:c123094-122822 [Vibrio cholerae O1 str. 2010EL-1786]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT25717 NC_016446:c123094-122822 [Vibrio cholerae O1 str. 2010EL-1786]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References