48151

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 364007..364585 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag IR04_RS01765 Protein ID WP_001180243.1
Coordinates 364007..364324 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag IR04_RS01770 Protein ID WP_000557292.1
Coordinates 364343..364585 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR04_RS01730 359198..359593 + 396 WP_000046952.1 hypothetical protein -
IR04_RS19280 359896..360077 + 182 Protein_347 DUF645 family protein -
IR04_RS01735 360254..360649 + 396 WP_000046953.1 hypothetical protein -
IR04_RS01740 360793..361329 + 537 WP_000644491.1 nucleotidyltransferase family protein -
IR04_RS01750 361626..361805 + 180 WP_001883039.1 DUF645 family protein -
IR04_RS01755 362001..362426 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
IR04_RS01760 362575..362922 + 348 WP_000933409.1 hypothetical protein -
IR04_RS20205 363069..363362 + 294 WP_125460920.1 hypothetical protein -
IR04_RS20395 363718..363813 + 96 WP_001907607.1 DUF645 family protein -
IR04_RS01765 364007..364324 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IR04_RS01770 364343..364585 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IR04_RS01775 364827..365336 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
IR04_RS01780 365393..366046 + 654 WP_000226874.1 hypothetical protein -
IR04_RS01785 366356..366574 + 219 WP_001917086.1 DUF3709 domain-containing protein -
IR04_RS19310 366977..367210 + 234 WP_032482776.1 DUF3709 domain-containing protein -
IR04_RS01790 367635..367815 + 181 Protein_361 DUF645 family protein -
IR04_RS01795 368082..368369 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
IR04_RS01800 368380..368697 + 318 WP_001232701.1 HigA family addiction module antidote protein -
IR04_RS20400 368694..368804 + 111 WP_134814058.1 DUF3265 domain-containing protein -
IR04_RS20405 368981..369106 + 126 WP_001944767.1 DUF645 family protein -
IR04_RS20410 369122..369160 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..409892 105192
inside Integron - - 309780..409516 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T48151 WP_001180243.1 NZ_CP009041:c364324-364007 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T48151 NZ_CP009041:c364324-364007 [Vibrio cholerae O1 biovar El Tor]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT48151 WP_000557292.1 NZ_CP009041:c364585-364343 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT48151 NZ_CP009041:c364585-364343 [Vibrio cholerae O1 biovar El Tor]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References