Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 364007..364585 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag IR04_RS01765 Protein ID WP_001180243.1
Coordinates 364007..364324 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag IR04_RS01770 Protein ID WP_000557292.1
Coordinates 364343..364585 (-) Length 81 a.a.

Genomic Context

IR04_RS01730IR04_RS19280IR04_RS01735IR04_RS01740IR04_RS01750IR04_RS01755IR04_RS01760IR04_RS20205IR04_RS20395IR04_RS01775IR04_RS01780IR04_RS01785IR04_RS19310IR04_RS01790IR04_RS01795IR04_RS01800IR04_RS20400IR04_RS20405IR04_RS20410IR04_RS01765IR04_RS01770
Location: 359198..359593 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 359896..360077 (182 bp)
Type: Others
Protein ID: Protein_347
Location: 360254..360649 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 360793..361329 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 361626..361805 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 362001..362426 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 362575..362922 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 363069..363362 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 363718..363813 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 364827..365336 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 365393..366046 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 366356..366574 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 366977..367210 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 367635..367815 (181 bp)
Type: Others
Protein ID: Protein_361
Location: 368082..368369 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 368380..368697 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 368694..368804 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 368981..369106 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 369122..369160 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 364007..364324 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 364343..364585 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IR04_RS01730359198..359593+396WP_000046952.1hypothetical protein-
IR04_RS19280359896..360077+182Protein_347DUF645 family protein-
IR04_RS01735360254..360649+396WP_000046953.1hypothetical protein-
IR04_RS01740360793..361329+537WP_000644491.1nucleotidyltransferase family protein-
IR04_RS01750361626..361805+180WP_001883039.1DUF645 family protein-
IR04_RS01755362001..362426+426WP_000403014.1GNAT family N-acetyltransferase-
IR04_RS01760362575..362922+348WP_000933409.1hypothetical protein-
IR04_RS20205363069..363362+294WP_125460920.1hypothetical protein-
IR04_RS20395363718..363813+96WP_001907607.1DUF645 family protein-
IR04_RS01765364007..364324-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IR04_RS01770364343..364585-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
IR04_RS01775364827..365336+510WP_000405987.1GNAT family N-acetyltransferase-
IR04_RS01780365393..366046+654WP_000226874.1hypothetical protein-
IR04_RS01785366356..366574+219WP_001917086.1DUF3709 domain-containing protein-
IR04_RS19310366977..367210+234WP_032482776.1DUF3709 domain-containing protein-
IR04_RS01790367635..367815+181Protein_361DUF645 family protein-
IR04_RS01795368082..368369+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
IR04_RS01800368380..368697+318WP_001232701.1HigA family addiction module antidote protein-
IR04_RS20400368694..368804+111WP_134814058.1DUF3265 domain-containing protein-
IR04_RS20405368981..369106+126WP_001944767.1DUF645 family protein-
IR04_RS20410369122..369160+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..409892105192
insideIntegron--309780..40951699736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T48151 WP_001180243.1 NZ_CP009041:c364324-364007 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T48151 NZ_CP009041:c364324-364007 [Vibrio cholerae O1 biovar El Tor]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT48151 WP_000557292.1 NZ_CP009041:c364585-364343 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT48151 NZ_CP009041:c364585-364343 [Vibrio cholerae O1 biovar El Tor]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References