58312

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 529713..530291 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ87_RS17155 Protein ID WP_001180243.1
Coordinates 529713..530030 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ87_RS17160 Protein ID WP_000557292.1
Coordinates 530049..530291 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ87_RS17105 524904..525299 + 396 WP_000046952.1 hypothetical protein -
ASZ87_RS17110 525602..525783 + 182 Protein_520 DUF645 family protein -
ASZ87_RS17115 525960..526355 + 396 WP_000046953.1 hypothetical protein -
ASZ87_RS17120 526499..527035 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ87_RS17125 527332..527511 + 180 WP_001883039.1 DUF645 family protein -
ASZ87_RS17130 527707..528132 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
ASZ87_RS17135 528281..528628 + 348 WP_000933409.1 hypothetical protein -
ASZ87_RS20720 528775..529068 + 294 WP_125460920.1 hypothetical protein -
ASZ87_RS21085 529424..529519 + 96 WP_001907607.1 DUF645 family protein -
ASZ87_RS17155 529713..530030 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ87_RS17160 530049..530291 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ87_RS17165 530533..531042 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
ASZ87_RS17170 531099..531752 + 654 WP_000226874.1 hypothetical protein -
ASZ87_RS17175 532062..532280 + 219 WP_001917086.1 DUF3709 domain-containing protein -
ASZ87_RS17185 532683..532916 + 234 WP_032482776.1 DUF3709 domain-containing protein -
ASZ87_RS17190 533341..533521 + 181 Protein_534 DUF645 family protein -
ASZ87_RS17195 533788..534075 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ87_RS17200 534086..534403 + 318 WP_001232701.1 HigA family addiction module antidote protein -
ASZ87_RS21090 534400..534510 + 111 WP_134814058.1 DUF3265 domain-containing protein -
ASZ87_RS21095 534687..534812 + 126 WP_001944767.1 DUF645 family protein -
ASZ87_RS21100 534828..534866 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 435534..596659 161125
inside Integron - - 440614..596283 155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58312 WP_001180243.1 NZ_CP013310:c530030-529713 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58312 NZ_CP013310:c530030-529713 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58312 WP_000557292.1 NZ_CP013310:c530291-530049 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58312 NZ_CP013310:c530291-530049 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References