Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 529713..530291 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ87_RS17155 Protein ID WP_001180243.1
Coordinates 529713..530030 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ87_RS17160 Protein ID WP_000557292.1
Coordinates 530049..530291 (-) Length 81 a.a.

Genomic Context

ASZ87_RS17105ASZ87_RS17110ASZ87_RS17115ASZ87_RS17120ASZ87_RS17125ASZ87_RS17130ASZ87_RS17135ASZ87_RS20720ASZ87_RS21085ASZ87_RS17165ASZ87_RS17170ASZ87_RS17175ASZ87_RS17185ASZ87_RS17190ASZ87_RS17195ASZ87_RS17200ASZ87_RS21090ASZ87_RS21095ASZ87_RS21100ASZ87_RS17155ASZ87_RS17160
Location: 524904..525299 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 525602..525783 (182 bp)
Type: Others
Protein ID: Protein_520
Location: 525960..526355 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 526499..527035 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 527332..527511 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 527707..528132 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 528281..528628 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 528775..529068 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 529424..529519 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 530533..531042 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 531099..531752 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 532062..532280 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 532683..532916 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 533341..533521 (181 bp)
Type: Others
Protein ID: Protein_534
Location: 533788..534075 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 534086..534403 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 534400..534510 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 534687..534812 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 534828..534866 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 529713..530030 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 530049..530291 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS17105524904..525299+396WP_000046952.1hypothetical protein-
ASZ87_RS17110525602..525783+182Protein_520DUF645 family protein-
ASZ87_RS17115525960..526355+396WP_000046953.1hypothetical protein-
ASZ87_RS17120526499..527035+537WP_000644491.1nucleotidyltransferase family protein-
ASZ87_RS17125527332..527511+180WP_001883039.1DUF645 family protein-
ASZ87_RS17130527707..528132+426WP_000403014.1GNAT family N-acetyltransferase-
ASZ87_RS17135528281..528628+348WP_000933409.1hypothetical protein-
ASZ87_RS20720528775..529068+294WP_125460920.1hypothetical protein-
ASZ87_RS21085529424..529519+96WP_001907607.1DUF645 family protein-
ASZ87_RS17155529713..530030-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ87_RS17160530049..530291-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ87_RS17165530533..531042+510WP_000405987.1GNAT family N-acetyltransferase-
ASZ87_RS17170531099..531752+654WP_000226874.1hypothetical protein-
ASZ87_RS17175532062..532280+219WP_001917086.1DUF3709 domain-containing protein-
ASZ87_RS17185532683..532916+234WP_032482776.1DUF3709 domain-containing protein-
ASZ87_RS17190533341..533521+181Protein_534DUF645 family protein-
ASZ87_RS17195533788..534075+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ87_RS17200534086..534403+318WP_001232701.1HigA family addiction module antidote protein-
ASZ87_RS21090534400..534510+111WP_134814058.1DUF3265 domain-containing protein-
ASZ87_RS21095534687..534812+126WP_001944767.1DUF645 family protein-
ASZ87_RS21100534828..534866+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58312 WP_001180243.1 NZ_CP013310:c530030-529713 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58312 NZ_CP013310:c530030-529713 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58312 WP_000557292.1 NZ_CP013310:c530291-530049 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58312 NZ_CP013310:c530291-530049 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References