254474

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 799543..800176 Replicon chromosome
Accession NZ_CP102928
Organism Vibrio cholerae strain N1252

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag NW313_RS17790 Protein ID WP_000843587.1
Coordinates 799543..799875 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NW313_RS17795 Protein ID WP_000071008.1
Coordinates 799862..800176 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW313_RS17735 794984..795187 + 204 WP_001911745.1 hypothetical protein -
NW313_RS17740 795444..795641 + 198 WP_001894451.1 DUF3709 domain-containing protein -
NW313_RS17745 796001..796270 + 270 WP_001198131.1 hypothetical protein -
NW313_RS17750 796606..796759 + 154 Protein_773 DUF645 family protein -
NW313_RS17755 796968..797354 + 387 WP_000703163.1 VOC family protein -
NW313_RS17760 797556..797798 + 243 WP_000107461.1 hypothetical protein -
NW313_RS17765 797969..798346 + 378 WP_000411109.1 hypothetical protein -
NW313_RS17770 798403..798517 + 115 Protein_777 acetyltransferase -
NW313_RS17775 798526..798747 + 222 WP_032468461.1 DUF1289 domain-containing protein -
NW313_RS17780 798913..799026 + 114 WP_001889158.1 hypothetical protein -
NW313_RS17785 798975..799202 + 228 WP_073426587.1 DUF1289 domain-containing protein -
NW313_RS17790 799543..799875 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW313_RS17795 799862..800176 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
NW313_RS17800 800313..800747 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
NW313_RS17805 800915..801070 + 156 WP_000751734.1 hypothetical protein -
NW313_RS17810 801195..802175 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
NW313_RS17815 802243..802549 + 307 Protein_786 CatB-related O-acetyltransferase -
NW313_RS17820 802686..803084 + 399 Protein_787 GNAT family N-acetyltransferase -
NW313_RS17825 803208..803378 + 171 WP_001080654.1 hypothetical protein -
NW313_RS17830 803378..803779 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
NW313_RS17835 803782..803892 + 111 WP_082798255.1 DUF3265 domain-containing protein -
NW313_RS17840 803967..804380 + 414 WP_000049417.1 VOC family protein -
NW313_RS17845 804594..804845 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
NW313_RS17850 804835..805122 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 713852..820357 106505
inside Integron catB9 - 718932..819981 101049
flank IS/Tn - - 801195..802175 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T254474 WP_000843587.1 NZ_CP102928:799543-799875 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT254474 WP_000071008.1 NZ_CP102928:799862-800176 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References