145891

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 388652..389289 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GTF74_RS15765 Protein ID WP_000869997.1
Coordinates 388930..389289 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag GTF74_RS15760 Protein ID WP_000086649.1
Coordinates 388652..388933 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF74_RS15725 383774..384133 + 360 WP_001071514.1 VOC family protein -
GTF74_RS15730 384316..384639 + 324 WP_001889156.1 DUF3709 domain-containing protein -
GTF74_RS15735 384920..385456 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF74_RS15740 386217..386399 + 183 WP_000947517.1 DUF645 family protein -
GTF74_RS15745 386518..387303 + 786 WP_001176447.1 hypothetical protein -
GTF74_RS15750 387405..387767 + 363 WP_170831679.1 DUF4144 domain-containing protein -
GTF74_RS15755 388013..388438 + 426 WP_000735184.1 hypothetical protein -
GTF74_RS15760 388652..388933 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF74_RS15765 388930..389289 + 360 WP_000869997.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF74_RS15770 389394..389717 + 324 WP_001999495.1 DUF3709 domain-containing protein -
GTF74_RS15775 390003..390398 + 396 WP_000870868.1 DUF3465 domain-containing protein -
GTF74_RS15780 390465..390579 + 115 Protein_402 acetyltransferase -
GTF74_RS15785 390588..390809 + 222 WP_043987927.1 DUF1289 domain-containing protein -
GTF74_RS15790 390785..390943 - 159 WP_001909351.1 DUF1196 family protein -
GTF74_RS15795 391173..391598 + 426 WP_000415748.1 hypothetical protein -
GTF74_RS15800 391924..392157 + 234 WP_001999499.1 DUF3709 domain-containing protein -
GTF74_RS15805 392346..392741 + 396 WP_001889207.1 DUF4144 domain-containing protein -
GTF74_RS15810 392960..393349 + 390 WP_000491261.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 307032..436751 129719
inside Integron - - 312112..436375 124263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13608.84 Da        Isoelectric Point: 8.1459

>T145891 WP_000869997.1 NZ_CP047304:388930-389289 [Vibrio cholerae O1 biovar El Tor]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTLRQEQTVNPPHNKRLKRDCQRVAFPVPLSRGGCSCCV

Download         Length: 360 bp

>T145891 NZ_CP062707:c24322-24140 [Escherichia coli O157:H7]
ATGAAATCTGCTGACCTGTTGAAAGAACTGATAGCTGCTGGTTGTGAGTTGAAGCGGCATAAGGCGAGCAGCCACCAGAT
ATGGTGGTCGCCCATAACAGGAAAAACTTTTCCTGTGCCCCATCCGAAAAAAGACTTGCCACTGGGTACTGTCAGATCGA
TCAGAAAAATGGCGGGGATTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT145891 WP_000086649.1 NZ_CP047304:388652-388933 [Vibrio cholerae O1 biovar El Tor]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT145891 NZ_CP062707:c24115-23678 [Escherichia coli O157:H7]
ATGTTTTTTTCTGTGGGTGTCGAAACACCGAAAGATGACCATACGGCATATGGTATAACCGTTCCGGCTTTTGATCGTTT
TGATTTTGGCTGTGTCTCTGCTGCCGATACTCAATCAGAAATTCCTGTGATGGCGCGAGAAGCGATATTGGCTATTGTGG
AAGAAATGGTTTTAAGTGGTTCTTATTCTGTTGATGATATTCATGATGACGGCTGTTTAACATATGCCGCAAATCAGGAC
TATAGTCACTGCGATAGCTGGTTTGTAATTGATGTTGATTTGTCTGAAATTGAAGGTAAACAACAACGTATTAATATTGC
GTTGCCTGATGTGTTGATTCGTCGTATTGATGGATTTGTCAGAGAAAGTGGCGGTGTTTACAGAGATCGTAGCCATTTTC
TTGCTCAGGCCGCGCGGCATGAGCTTTCATATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References