Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 397510..398038 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag VCA1552_RS16555 Protein ID WP_000221352.1
Coordinates 397510..397800 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag VCA1552_RS16560 Protein ID WP_000213183.1
Coordinates 397790..398038 (-) Length 83 a.a.

Genomic Context

VCA1552_RS20020VCA1552_RS20025VCA1552_RS16525VCA1552_RS16530VCA1552_RS16535VCA1552_RS16540VCA1552_RS16545VCA1552_RS16550VCA1552_RS16575VCA1552_RS16580VCA1552_RS16585VCA1552_RS16590VCA1552_RS16595VCA1552_RS16605VCA1552_RS16555VCA1552_RS16560VCA1552_RS16610
Location: 393067..393192 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 393208..393246 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 393459..394463 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 394616..395062 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 395182..396111 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 396108..396218 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 396246..396722 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 396859..397374 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 398609..399262 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 399534..399959 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 400167..400562 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 400713..401243 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 401381..401881 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 402037..402435 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 397510..397800 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 397790..398038 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 402535..402999 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCA1552_RS20020393067..393192+126WP_001944767.1DUF645 family protein-
VCA1552_RS20025393208..393246+39WP_106019119.1hypothetical protein-
VCA1552_RS16525393459..394463+1005WP_000964925.1LD-carboxypeptidase-
VCA1552_RS16530394616..395062+447WP_000128977.1hypothetical protein-
VCA1552_RS16535395182..396111+930WP_000335802.1hypothetical protein-
VCA1552_RS16540396108..396218+111WP_071917832.1DUF3265 domain-containing protein-
VCA1552_RS16545396246..396722+477WP_001047180.1GNAT family N-acetyltransferase-
VCA1552_RS16550396859..397374+516WP_001201528.1lipocalin family protein-
VCA1552_RS16555397510..397800-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VCA1552_RS16560397790..398038-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
VCA1552_RS16575398609..399262+654WP_000036957.1site-specific DNA-methyltransferase-
VCA1552_RS16580399534..399959+426WP_000415748.1hypothetical protein-
VCA1552_RS16585400167..400562+396WP_000649527.1DUF3465 domain-containing protein-
VCA1552_RS16590400713..401243+531WP_000415563.1hypothetical protein-
VCA1552_RS16595401381..401881+501WP_000789723.1hypothetical protein-
VCA1552_RS16605402037..402435+399WP_001882293.1hypothetical protein-
VCA1552_RS16610402535..402999-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304717..433978129261
insideIntegron--309797..433602123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T88995 WP_000221352.1 NZ_CP024868:c397800-397510 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T88995 NZ_CP024868:c397800-397510 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT88995 WP_000213183.1 NZ_CP024868:c398038-397790 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT88995 NZ_CP024868:c398038-397790 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References