88995

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 397510..398038 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag VCA1552_RS16555 Protein ID WP_000221352.1
Coordinates 397510..397800 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag VCA1552_RS16560 Protein ID WP_000213183.1
Coordinates 397790..398038 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCA1552_RS20020 393067..393192 + 126 WP_001944767.1 DUF645 family protein -
VCA1552_RS20025 393208..393246 + 39 WP_106019119.1 hypothetical protein -
VCA1552_RS16525 393459..394463 + 1005 WP_000964925.1 LD-carboxypeptidase -
VCA1552_RS16530 394616..395062 + 447 WP_000128977.1 hypothetical protein -
VCA1552_RS16535 395182..396111 + 930 WP_000335802.1 hypothetical protein -
VCA1552_RS16540 396108..396218 + 111 WP_071917832.1 DUF3265 domain-containing protein -
VCA1552_RS16545 396246..396722 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
VCA1552_RS16550 396859..397374 + 516 WP_001201528.1 lipocalin family protein -
VCA1552_RS16555 397510..397800 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCA1552_RS16560 397790..398038 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VCA1552_RS16575 398609..399262 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
VCA1552_RS16580 399534..399959 + 426 WP_000415748.1 hypothetical protein -
VCA1552_RS16585 400167..400562 + 396 WP_000649527.1 DUF3465 domain-containing protein -
VCA1552_RS16590 400713..401243 + 531 WP_000415563.1 hypothetical protein -
VCA1552_RS16595 401381..401881 + 501 WP_000789723.1 hypothetical protein -
VCA1552_RS16605 402037..402435 + 399 WP_001882293.1 hypothetical protein -
VCA1552_RS16610 402535..402999 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304717..433978 129261
inside Integron - - 309797..433602 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T88995 WP_000221352.1 NZ_CP024868:c397800-397510 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T88995 NZ_CP024868:c397800-397510 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT88995 WP_000213183.1 NZ_CP024868:c398038-397790 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT88995 NZ_CP024868:c398038-397790 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References