Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 395548..396046 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag ASZ85_RS16205 Protein ID WP_000589156.1
Coordinates 395548..395814 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag ASZ85_RS16210 Protein ID WP_000643598.1
Coordinates 395801..396046 (+) Length 82 a.a.

Genomic Context

ASZ85_RS21045ASZ85_RS16165ASZ85_RS16175ASZ85_RS16180ASZ85_RS21450ASZ85_RS16185ASZ85_RS16190ASZ85_RS16195ASZ85_RS16200ASZ85_RS16205ASZ85_RS16210ASZ85_RS16215ASZ85_RS21455ASZ85_RS16230ASZ85_RS16235ASZ85_RS16240ASZ85_RS16245ASZ85_RS16250ASZ85_RS16255
Location: 390688..390777 (90 bp)
Type: Others
Protein ID: WP_131065139.1
Location: 390770..391633 (864 bp)
Type: Others
Protein ID: WP_001900189.1
Location: 391876..392154 (279 bp)
Type: Others
Protein ID: WP_000280319.1
Location: 392423..392959 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 393078..393239 (162 bp)
Type: Others
Protein ID: WP_000481782.1
Location: 393428..393538 (111 bp)
Type: Others
Protein ID: WP_071908335.1
Location: 393590..393943 (354 bp)
Type: Others
Protein ID: WP_000384364.1
Location: 394106..394573 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 394701..395363 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 395548..395814 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 395801..396046 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 396142..396936 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 397039..397167 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 397228..397410 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 397626..398630 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 398783..399142 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 399415..399648 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 399916..400422 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 400579..400965 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ85_RS21045390688..390777+90WP_131065139.1acetyltransferase-
ASZ85_RS16165390770..391633+864WP_001900189.1hypothetical protein-
ASZ85_RS16175391876..392154+279WP_000280319.1DUF3709 domain-containing protein-
ASZ85_RS16180392423..392959+537WP_000644491.1nucleotidyltransferase family protein-
ASZ85_RS21450393078..393239+162WP_000481782.1hypothetical protein-
ASZ85_RS16185393428..393538+111WP_071908335.1DUF3265 domain-containing protein-
ASZ85_RS16190393590..393943+354WP_000384364.1hypothetical protein-
ASZ85_RS16195394106..394573+468WP_001289288.1OsmC family protein-
ASZ85_RS16200394701..395363+663WP_000960654.1hypothetical protein-
ASZ85_RS16205395548..395814+267WP_000589156.1BrnT family toxinToxin
ASZ85_RS16210395801..396046+246WP_000643598.1hypothetical proteinAntitoxin
ASZ85_RS16215396142..396936+795WP_001911581.1hypothetical protein-
ASZ85_RS21455397039..397167+129WP_071908338.1general secretion pathway protein GspI-
ASZ85_RS16230397228..397410+183WP_000923182.1DUF645 family protein-
ASZ85_RS16235397626..398630+1005WP_000964920.1LD-carboxypeptidase-
ASZ85_RS16240398783..399142+360WP_001071541.1VOC family protein-
ASZ85_RS16245399415..399648+234WP_001890112.1DUF3709 domain-containing protein-
ASZ85_RS16250399916..400422+507WP_000393074.1hypothetical protein-
ASZ85_RS16255400579..400965+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--338285..496833158548
insideIntegron--343365..496457153092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T58398 WP_000589156.1 NZ_CP013318:395548-395814 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T58398 NZ_CP013318:395548-395814 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT58398 WP_000643598.1 NZ_CP013318:395801-396046 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT58398 NZ_CP013318:395801-396046 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References