Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 134707..135205 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag ASZ83_RS14770 Protein ID WP_000589156.1
Coordinates 134707..134973 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag ASZ83_RS14775 Protein ID WP_000643598.1
Coordinates 134960..135205 (+) Length 82 a.a.

Genomic Context

ASZ83_RS14725ASZ83_RS14730ASZ83_RS14735ASZ83_RS14740ASZ83_RS14745ASZ83_RS20440ASZ83_RS20445ASZ83_RS14760ASZ83_RS14765ASZ83_RS14770ASZ83_RS14775ASZ83_RS14780ASZ83_RS20450ASZ83_RS14795ASZ83_RS14800ASZ83_RS14805ASZ83_RS14810ASZ83_RS14815ASZ83_RS14820
Location: 129939..130475 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 130944..131054 (111 bp)
Type: Others
Protein ID: WP_071908335.1
Location: 131106..131459 (354 bp)
Type: Others
Protein ID: WP_000384364.1
Location: 131671..131913 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 132165..132443 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 132818..132961 (144 bp)
Type: Others
Protein ID: Protein_154
Location: 133015..133053 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 133265..133732 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 133860..134522 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 134707..134973 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 134960..135205 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 135301..136095 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 136198..136326 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 136387..136569 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 136785..137789 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 137942..138301 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 138574..138807 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 139075..139581 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 139738..140124 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ83_RS14725129939..130475+537WP_000644491.1nucleotidyltransferase family protein-
ASZ83_RS14730130944..131054+111WP_071908335.1DUF3265 domain-containing protein-
ASZ83_RS14735131106..131459+354WP_000384364.1hypothetical protein-
ASZ83_RS14740131671..131913+243WP_000107461.1hypothetical protein-
ASZ83_RS14745132165..132443+279WP_000280324.1DUF3709 domain-containing protein-
ASZ83_RS20440132818..132961+144Protein_154DUF645 family protein-
ASZ83_RS20445133015..133053+39WP_082798268.1hypothetical protein-
ASZ83_RS14760133265..133732+468WP_001289288.1OsmC family protein-
ASZ83_RS14765133860..134522+663WP_000960654.1hypothetical protein-
ASZ83_RS14770134707..134973+267WP_000589156.1BrnT family toxinToxin
ASZ83_RS14775134960..135205+246WP_000643598.1hypothetical proteinAntitoxin
ASZ83_RS14780135301..136095+795WP_001911581.1hypothetical protein-
ASZ83_RS20450136198..136326+129WP_071908338.1general secretion pathway protein GspI-
ASZ83_RS14795136387..136569+183WP_000923182.1DUF645 family protein-
ASZ83_RS14800136785..137789+1005WP_000964920.1LD-carboxypeptidase-
ASZ83_RS14805137942..138301+360WP_001071541.1VOC family protein-
ASZ83_RS14810138574..138807+234WP_001890112.1DUF3709 domain-containing protein-
ASZ83_RS14815139075..139581+507WP_000393074.1hypothetical protein-
ASZ83_RS14820139738..140124+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--87981..224211136230
insideIntegron--93061..221594128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T58377 WP_000589156.1 NZ_CP013316:134707-134973 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T58377 NZ_CP013316:134707-134973 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT58377 WP_000643598.1 NZ_CP013316:134960-135205 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT58377 NZ_CP013316:134960-135205 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References