Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 943018..943817 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag K1T75_RS17860 Protein ID WP_000118351.1
Coordinates 943018..943551 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag K1T75_RS18840 Protein ID WP_000179600.1
Coordinates 943548..943817 (-) Length 90 a.a.

Genomic Context

K1T75_RS17885K1T75_RS17890K1T75_RS17820K1T75_RS17825K1T75_RS17830K1T75_RS17835K1T75_RS17840K1T75_RS17845K1T75_RS17850K1T75_RS17855K1T75_RS18835K1T75_RS17860K1T75_RS18840K1T75_RS17870K1T75_RS17875K1T75_RS17880K1T75_RS18845K1T75_RS18850K1T75_RS17895K1T75_RS18855K1T75_RS17900K1T75_RS17905K1T75_RS17910
Location: 945890..946162 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 946159..946656 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 938342..939214 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 939389..939610 (222 bp)
Type: Others
Protein ID: Protein_808
Location: 939671..940108 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 940227..940436 (210 bp)
Type: Others
Protein ID: Protein_810
Location: 940572..940961 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 941118..942035 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 942269..942571 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 942559..942816 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 942898..943008 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 943018..943551 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 943548..943817 (270 bp)
Type: Antitoxin
Protein ID: WP_000179600.1
Location: 944040..944411 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 944552..944839 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 944991..945659 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 945676..945738 (63 bp)
Type: Others
Protein ID: Protein_821
Location: 946673..946741 (69 bp)
Type: Others
Protein ID: Protein_824
Location: 946858..946962 (105 bp)
Type: Others
Protein ID: WP_228840819.1
Location: 947153..947275 (123 bp)
Type: Others
Protein ID: Protein_826
Location: 947332..947787 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 947915..948202 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 948192..948443 (252 bp)
Type: Others
Protein ID: WP_001250179.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K1T75_RS17820938342..939214-873WP_000254716.1DUF3800 domain-containing protein-
K1T75_RS17825939389..939610-222Protein_808GNAT family N-acetyltransferase-
K1T75_RS17830939671..940108-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
K1T75_RS17835940227..940436-210Protein_810GNAT family N-acetyltransferase-
K1T75_RS17840940572..940961-390WP_001081302.1hypothetical protein-
K1T75_RS17845941118..942035-918WP_000186333.1alpha/beta hydrolase-
K1T75_RS17850942269..942571-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
K1T75_RS17855942559..942816-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K1T75_RS18835942898..943008-111WP_086010065.1DUF3265 domain-containing protein-
K1T75_RS17860943018..943551-534WP_000118351.1GNAT family N-acetyltransferaseToxin
K1T75_RS18840943548..943817-270WP_000179600.1DUF1778 domain-containing proteinAntitoxin
K1T75_RS17870944040..944411-372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
K1T75_RS17875944552..944839-288WP_000426470.1hypothetical protein-
K1T75_RS17880944991..945659-669WP_000043871.1hypothetical protein-
K1T75_RS18845945676..945738-63Protein_821acetyltransferase-
K1T75_RS17885945890..946162+273WP_000246253.1DUF1778 domain-containing protein-
K1T75_RS17890946159..946656+498WP_000982260.1GNAT family N-acetyltransferase-
K1T75_RS18850946673..946741-69Protein_824acetyltransferase-
K1T75_RS17895946858..946962-105WP_228840819.1DUF645 family protein-
K1T75_RS18855947153..947275-123Protein_826acetyltransferase-
K1T75_RS17900947332..947787-456WP_001245327.1GNAT family N-acetyltransferase-
K1T75_RS17905947915..948202-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
K1T75_RS17910948192..948443-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932680..1039634106954
insideIntegron--933056..103279299736
flankIS/Tn--939671..940108437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T211909 WP_000118351.1 NZ_CP080466:c943551-943018 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T211909 NZ_CP106838:2967238-2967648 [Klebsiella michiganensis]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCT
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT211909 WP_000179600.1 NZ_CP080466:c943817-943548 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp

>AT211909 NZ_CP106838:2966991-2967257 [Klebsiella michiganensis]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGACAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0K9UER4

References