Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
Location | 943018..943817 | Replicon | chromosome |
Accession | NZ_CP080466 | ||
Organism | Vibrio cholerae strain ICDC-VC3741 |
Toxin (Protein)
Gene name | - | Uniprot ID | Q9KM94 |
Locus tag | K1T75_RS17860 | Protein ID | WP_000118351.1 |
Coordinates | 943018..943551 (-) | Length | 178 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A0K9UER4 |
Locus tag | K1T75_RS18840 | Protein ID | WP_000179600.1 |
Coordinates | 943548..943817 (-) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K1T75_RS17820 | 938342..939214 | - | 873 | WP_000254716.1 | DUF3800 domain-containing protein | - |
K1T75_RS17825 | 939389..939610 | - | 222 | Protein_808 | GNAT family N-acetyltransferase | - |
K1T75_RS17830 | 939671..940108 | - | 438 | WP_000503169.1 | IS200/IS605-like element IS1004 family transposase | - |
K1T75_RS17835 | 940227..940436 | - | 210 | Protein_810 | GNAT family N-acetyltransferase | - |
K1T75_RS17840 | 940572..940961 | - | 390 | WP_001081302.1 | hypothetical protein | - |
K1T75_RS17845 | 941118..942035 | - | 918 | WP_000186333.1 | alpha/beta hydrolase | - |
K1T75_RS17850 | 942269..942571 | - | 303 | WP_000229317.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
K1T75_RS17855 | 942559..942816 | - | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
K1T75_RS18835 | 942898..943008 | - | 111 | WP_086010065.1 | DUF3265 domain-containing protein | - |
K1T75_RS17860 | 943018..943551 | - | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | Toxin |
K1T75_RS18840 | 943548..943817 | - | 270 | WP_000179600.1 | DUF1778 domain-containing protein | Antitoxin |
K1T75_RS17870 | 944040..944411 | - | 372 | WP_001164080.1 | MazG nucleotide pyrophosphohydrolase domain-containing protein | - |
K1T75_RS17875 | 944552..944839 | - | 288 | WP_000426470.1 | hypothetical protein | - |
K1T75_RS17880 | 944991..945659 | - | 669 | WP_000043871.1 | hypothetical protein | - |
K1T75_RS18845 | 945676..945738 | - | 63 | Protein_821 | acetyltransferase | - |
K1T75_RS17885 | 945890..946162 | + | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
K1T75_RS17890 | 946159..946656 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
K1T75_RS18850 | 946673..946741 | - | 69 | Protein_824 | acetyltransferase | - |
K1T75_RS17895 | 946858..946962 | - | 105 | WP_228840819.1 | DUF645 family protein | - |
K1T75_RS18855 | 947153..947275 | - | 123 | Protein_826 | acetyltransferase | - |
K1T75_RS17900 | 947332..947787 | - | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
K1T75_RS17905 | 947915..948202 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
K1T75_RS17910 | 948192..948443 | - | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 932680..1039634 | 106954 | |
inside | Integron | - | - | 933056..1032792 | 99736 | ||
flank | IS/Tn | - | - | 939671..940108 | 437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 20171.46 Da Isoelectric Point: 9.1432
>T211909 WP_000118351.1 NZ_CP080466:c943551-943018 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
Download Length: 534 bp
>T211909 NZ_CP106838:2967238-2967648 [Klebsiella michiganensis]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCT
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCT
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 9924.49 Da Isoelectric Point: 4.9107
>AT211909 WP_000179600.1 NZ_CP080466:c943817-943548 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK
Download Length: 270 bp
>AT211909 NZ_CP106838:2966991-2967257 [Klebsiella michiganensis]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGACAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGACAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q9KM94 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0K9UER4 |