Detailed information of TA system TA058305

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 471684..472534
• Replicon: chromosome
• Accession: NZ_CP013310
• Organism: Vibrio cholerae strain E1162

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KM94
• Locus tag: ASZ87_RS16605
• Protein ID: WP_000118351.1
• Coordinates: 472001..472534 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ASZ87_RS16600
• Protein ID: WP_001909340.1
• Coordinates: 471684..472004 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ87_RS16560	467020..467502	+	483	WP_000422940.1	GNAT family N-acetyltransferase	-
ASZ87_RS16570	468310..468579	+	270	WP_001114075.1	DUF4160 domain-containing protein	-
ASZ87_RS16575	468573..469094	+	522	WP_000921692.1	DUF2442 domain-containing protein	-
ASZ87_RS20580	469151..469264	+	114	WP_001894981.1	hypothetical protein	-
ASZ87_RS16580	469233..470069	+	837	WP_000242986.1	hypothetical protein	-
ASZ87_RS16585	470234..470872	+	639	WP_000230118.1	HD domain-containing protein	-
ASZ87_RS20585	470962..471122	+	161	Protein_424	DUF3709 domain-containing protein	-
ASZ87_RS16590	471143..471364	+	222	WP_012705854.1	DUF3709 domain-containing protein	-
ASZ87_RS16600	471684..472004	+	321	WP_001909340.1	DUF1778 domain-containing protein	Antitoxin
ASZ87_RS16605	472001..472534	+	534	WP_000118351.1	GNAT family N-acetyltransferase	Toxin
ASZ87_RS16610	472772..473050	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
ASZ87_RS16615	473451..473675	+	225	WP_001894423.1	DUF3709 domain-containing protein	-
ASZ87_RS16625	474413..474802	+	390	WP_000491263.1	VOC family protein	-
ASZ87_RS16630	474935..475450	+	516	WP_000090008.1	hypothetical protein	-
ASZ87_RS16635	475591..476028	+	438	WP_001202554.1	NUDIX pyrophosphatase	-
ASZ87_RS16640	476189..476536	+	348	WP_000933409.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	435534..596659	161125
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.005	inside	Integron	-	-	440614..596283	155669

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (22-98)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20171.46 Da
• Isoelectric Point: 9.1432

>T58305 WP_000118351.1 NZ_CP013310:472001-472534 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T58305 NZ_CP013310:472001-472534 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11759.53 Da
• Isoelectric Point: 4.9309

>AT58305 WP_001909340.1 NZ_CP013310:471684-472004 [Vibrio cholerae]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 321 bp

>AT58305 NZ_CP013310:471684-472004 [Vibrio cholerae]
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A

Structures

Toxin

• AlphaFold DB: Q9KM94