Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 471684..472534 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag ASZ87_RS16605 Protein ID WP_000118351.1
Coordinates 472001..472534 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ASZ87_RS16600 Protein ID WP_001909340.1
Coordinates 471684..472004 (+) Length 107 a.a.

Genomic Context

ASZ87_RS16560ASZ87_RS16570ASZ87_RS16575ASZ87_RS20580ASZ87_RS16580ASZ87_RS16585ASZ87_RS20585ASZ87_RS16590ASZ87_RS16600ASZ87_RS16605ASZ87_RS16610ASZ87_RS16615ASZ87_RS16625ASZ87_RS16630ASZ87_RS16635ASZ87_RS16640
Location: 467020..467502 (483 bp)
Type: Others
Protein ID: WP_000422940.1
Location: 468310..468579 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 468573..469094 (522 bp)
Type: Others
Protein ID: WP_000921692.1
Location: 469151..469264 (114 bp)
Type: Others
Protein ID: WP_001894981.1
Location: 469233..470069 (837 bp)
Type: Others
Protein ID: WP_000242986.1
Location: 470234..470872 (639 bp)
Type: Others
Protein ID: WP_000230118.1
Location: 470962..471122 (161 bp)
Type: Others
Protein ID: Protein_424
Location: 471143..471364 (222 bp)
Type: Others
Protein ID: WP_012705854.1
Location: 471684..472004 (321 bp)
Type: Antitoxin
Protein ID: WP_001909340.1
Location: 472001..472534 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 472772..473050 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 473451..473675 (225 bp)
Type: Others
Protein ID: WP_001894423.1
Location: 474413..474802 (390 bp)
Type: Others
Protein ID: WP_000491263.1
Location: 474935..475450 (516 bp)
Type: Others
Protein ID: WP_000090008.1
Location: 475591..476028 (438 bp)
Type: Others
Protein ID: WP_001202554.1
Location: 476189..476536 (348 bp)
Type: Others
Protein ID: WP_000933409.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS16560467020..467502+483WP_000422940.1GNAT family N-acetyltransferase-
ASZ87_RS16570468310..468579+270WP_001114075.1DUF4160 domain-containing protein-
ASZ87_RS16575468573..469094+522WP_000921692.1DUF2442 domain-containing protein-
ASZ87_RS20580469151..469264+114WP_001894981.1hypothetical protein-
ASZ87_RS16580469233..470069+837WP_000242986.1hypothetical protein-
ASZ87_RS16585470234..470872+639WP_000230118.1HD domain-containing protein-
ASZ87_RS20585470962..471122+161Protein_424DUF3709 domain-containing protein-
ASZ87_RS16590471143..471364+222WP_012705854.1DUF3709 domain-containing protein-
ASZ87_RS16600471684..472004+321WP_001909340.1DUF1778 domain-containing proteinAntitoxin
ASZ87_RS16605472001..472534+534WP_000118351.1GNAT family N-acetyltransferaseToxin
ASZ87_RS16610472772..473050+279WP_000280324.1DUF3709 domain-containing protein-
ASZ87_RS16615473451..473675+225WP_001894423.1DUF3709 domain-containing protein-
ASZ87_RS16625474413..474802+390WP_000491263.1VOC family protein-
ASZ87_RS16630474935..475450+516WP_000090008.1hypothetical protein-
ASZ87_RS16635475591..476028+438WP_001202554.1NUDIX pyrophosphatase-
ASZ87_RS16640476189..476536+348WP_000933409.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(22-98)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T58305 WP_000118351.1 NZ_CP013310:472001-472534 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T58305 NZ_CP013310:472001-472534 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11759.53 Da        Isoelectric Point: 4.9309

>AT58305 WP_001909340.1 NZ_CP013310:471684-472004 [Vibrio cholerae]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 321 bp

>AT58305 NZ_CP013310:471684-472004 [Vibrio cholerae]
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References