293802

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 418090..419183 Replicon chromosome
Accession NZ_LT906615
Organism Vibrio cholerae O1 biovar El Tor str. N16961

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag FY484_RS16400 Protein ID WP_000351248.1
Coordinates 418782..419183 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag FY484_RS16395 Protein ID WP_001047169.1
Coordinates 418090..418782 (+) Length 231 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY484_RS16330 413373..413750 + 378 WP_000411109.1 hypothetical protein -
FY484_RS19560 413807..413921 + 115 Protein_437 acetyltransferase -
FY484_RS16335 413870..414151 + 282 WP_001894453.1 DUF1289 domain-containing protein -
FY484_RS16350 414317..414430 + 114 WP_001889158.1 hypothetical protein -
FY484_RS16355 414379..414606 + 228 WP_001894457.1 DUF1289 domain-containing protein -
FY484_RS16370 414947..415279 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
FY484_RS16375 415266..415580 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
FY484_RS16380 415717..416151 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
FY484_RS19565 416319..416474 + 156 WP_000751734.1 hypothetical protein -
FY484_RS16385 416599..417579 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
FY484_RS16390 417647..417953 + 307 Protein_446 CatB-related O-acetyltransferase -
FY484_RS16395 418090..418782 + 693 WP_001047169.1 GNAT family N-acetyltransferase Antitoxin
FY484_RS16400 418782..419183 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FY484_RS16405 419153..419296 + 144 WP_071908341.1 DUF3265 domain-containing protein -
FY484_RS16410 419371..419784 + 414 WP_000049417.1 VOC family protein -
FY484_RS16415 419998..420249 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FY484_RS16420 420239..420526 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
FY484_RS16425 420654..421109 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
FY484_RS16430 421431..421583 + 153 WP_001884520.1 DUF645 family protein -
FY484_RS16440 421785..422282 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
FY484_RS16445 422279..422551 - 273 WP_000246253.1 DUF1778 domain-containing protein -
FY484_RS16450 422782..423450 + 669 WP_000043871.1 hypothetical protein -
FY484_RS16455 423602..423889 + 288 WP_000426470.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304666..435761 131095
inside Integron catB9 - 309746..435385 125639
flank IS/Tn - - 416599..417579 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-132)

Antitoxin

(36-153)


Sequences


Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T293802 WP_000351248.1 NZ_LT906615:418782-419183 [Vibrio cholerae O1 biovar El Tor str. N16961]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp


Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT293802 WP_001047169.1 NZ_LT906615:418090-418782 [Vibrio cholerae O1 biovar El Tor str. N16961]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34


Antitoxin

Source ID Structure

References