145868

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 343132..343691 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GTF75_RS15515 Protein ID WP_000578476.1
Coordinates 343132..343410 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GTF75_RS15520 Protein ID WP_000381183.1
Coordinates 343407..343691 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF75_RS15465 338210..338716 + 507 WP_000393074.1 hypothetical protein -
GTF75_RS15470 338873..339259 + 387 WP_000703163.1 VOC family protein -
GTF75_RS15475 339516..339719 + 204 WP_001911580.1 hypothetical protein -
GTF75_RS15480 339914..340165 + 252 WP_001890111.1 TIGR03643 family protein -
GTF75_RS15485 340138..340287 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GTF75_RS15490 340434..340859 + 426 WP_000415750.1 hypothetical protein -
GTF75_RS15495 341065..341688 + 624 WP_000247070.1 DUF1349 domain-containing protein -
GTF75_RS15500 341901..342380 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
GTF75_RS15505 342568..342981 + 414 WP_000049420.1 VOC family protein -
GTF75_RS15510 342988..343083 - 96 Protein_321 hypothetical protein -
GTF75_RS15515 343132..343410 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GTF75_RS15520 343407..343691 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTF75_RS15525 343886..344401 + 516 WP_001201520.1 lipocalin family protein -
GTF75_RS15530 344466..345062 + 597 WP_000255434.1 hypothetical protein -
GTF75_RS15535 345454..345636 + 183 WP_000923182.1 DUF645 family protein -
GTF75_RS15540 345836..346309 + 474 WP_001161076.1 GrpB family protein -
GTF75_RS15545 346306..346416 + 111 WP_071908312.1 DUF3265 domain-containing protein -
GTF75_RS15550 346458..347084 + 627 WP_000365424.1 LysE family translocator -
GTF75_RS15555 347207..347905 + 699 WP_001890502.1 hypothetical protein -
GTF75_RS15560 347909..348025 + 117 WP_071908339.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305935..411136 105201
inside Integron - - 311015..410760 99745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145868 WP_000578476.1 NZ_CP047302:c343410-343132 [Vibrio cholerae O1 biovar El Tor]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145868 NZ_CP062705:752670-752984 [Escherichia coli O157:H7]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145868 WP_000381183.1 NZ_CP047302:c343691-343407 [Vibrio cholerae O1 biovar El Tor]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145868 NZ_CP062705:752981-753397 [Escherichia coli O157:H7]
ATGATTGCGATTGCCGACATCTTGCATGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACATCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References