Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 343132..343691 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GTF75_RS15515 Protein ID WP_000578476.1
Coordinates 343132..343410 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GTF75_RS15520 Protein ID WP_000381183.1
Coordinates 343407..343691 (-) Length 95 a.a.

Genomic Context

GTF75_RS15465GTF75_RS15470GTF75_RS15475GTF75_RS15480GTF75_RS15485GTF75_RS15490GTF75_RS15495GTF75_RS15500GTF75_RS15505GTF75_RS15525GTF75_RS15530GTF75_RS15535GTF75_RS15540GTF75_RS15545GTF75_RS15550GTF75_RS15555GTF75_RS15560GTF75_RS15510GTF75_RS15515GTF75_RS15520
Location: 338210..338716 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 338873..339259 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 339516..339719 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 339914..340165 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 340138..340287 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 340434..340859 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 341065..341688 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 341901..342380 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 342568..342981 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 343886..344401 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 344466..345062 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 345454..345636 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 345836..346309 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 346306..346416 (111 bp)
Type: Others
Protein ID: WP_071908312.1
Location: 346458..347084 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 347207..347905 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 347909..348025 (117 bp)
Type: Others
Protein ID: WP_071908339.1
Location: 342988..343083 (96 bp)
Type: Others
Protein ID: Protein_321
Location: 343132..343410 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 343407..343691 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF75_RS15465338210..338716+507WP_000393074.1hypothetical protein-
GTF75_RS15470338873..339259+387WP_000703163.1VOC family protein-
GTF75_RS15475339516..339719+204WP_001911580.1hypothetical protein-
GTF75_RS15480339914..340165+252WP_001890111.1TIGR03643 family protein-
GTF75_RS15485340138..340287+150WP_071908333.1DUF3265 domain-containing protein-
GTF75_RS15490340434..340859+426WP_000415750.1hypothetical protein-
GTF75_RS15495341065..341688+624WP_000247070.1DUF1349 domain-containing protein-
GTF75_RS15500341901..342380+480WP_000009888.1lecithin retinol acyltransferase family protein-
GTF75_RS15505342568..342981+414WP_000049420.1VOC family protein-
GTF75_RS15510342988..343083-96Protein_321hypothetical protein-
GTF75_RS15515343132..343410-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
GTF75_RS15520343407..343691-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
GTF75_RS15525343886..344401+516WP_001201520.1lipocalin family protein-
GTF75_RS15530344466..345062+597WP_000255434.1hypothetical protein-
GTF75_RS15535345454..345636+183WP_000923182.1DUF645 family protein-
GTF75_RS15540345836..346309+474WP_001161076.1GrpB family protein-
GTF75_RS15545346306..346416+111WP_071908312.1DUF3265 domain-containing protein-
GTF75_RS15550346458..347084+627WP_000365424.1LysE family translocator-
GTF75_RS15555347207..347905+699WP_001890502.1hypothetical protein-
GTF75_RS15560347909..348025+117WP_071908339.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305935..411136105201
insideIntegron--311015..41076099745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145868 WP_000578476.1 NZ_CP047302:c343410-343132 [Vibrio cholerae O1 biovar El Tor]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145868 NZ_CP062705:752670-752984 [Escherichia coli O157:H7]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145868 WP_000381183.1 NZ_CP047302:c343691-343407 [Vibrio cholerae O1 biovar El Tor]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145868 NZ_CP062705:752981-753397 [Escherichia coli O157:H7]
ATGATTGCGATTGCCGACATCTTGCATGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACATCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References