Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 463743..464527 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ79_RS17030 Protein ID WP_001114075.1
Coordinates 463743..464012 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag ASZ79_RS17035 Protein ID WP_000921691.1
Coordinates 464006..464527 (+) Length 174 a.a.

Genomic Context

ASZ79_RS16985ASZ79_RS16995ASZ79_RS17000ASZ79_RS17005ASZ79_RS17010ASZ79_RS17020ASZ79_RS17025ASZ79_RS20765ASZ79_RS17030ASZ79_RS17035ASZ79_RS20770ASZ79_RS17050ASZ79_RS17065ASZ79_RS17070ASZ79_RS17085ASZ79_RS17055ASZ79_RS17060
Location: 459109..460026 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 460183..460572 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 460708..460917 (210 bp)
Type: Others
Protein ID: Protein_519
Location: 461036..461473 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 461537..461755 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 461930..462802 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 462952..463551 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 463608..463712 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 463743..464012 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 464006..464527 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 464826..464951 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 465202..465597 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 466489..467004 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 467188..467601 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 468156..469333 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 465736..466014 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 466011..466295 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ79_RS16985459109..460026+918WP_000186333.1alpha/beta hydrolase-
ASZ79_RS16995460183..460572+390WP_001081302.1hypothetical protein-
ASZ79_RS17000460708..460917+210Protein_519GNAT family N-acetyltransferase-
ASZ79_RS17005461036..461473+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ79_RS17010461537..461755+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ79_RS17020461930..462802+873WP_000254716.1DUF3800 domain-containing protein-
ASZ79_RS17025462952..463551+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ79_RS20765463608..463712+105WP_099607150.1acetyltransferase-
ASZ79_RS17030463743..464012+270WP_001114075.1DUF4160 domain-containing proteinToxin
ASZ79_RS17035464006..464527+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
ASZ79_RS20770464826..464951+126WP_001905700.1DUF645 family protein-
ASZ79_RS17050465202..465597+396WP_001000867.1hypothetical protein-
ASZ79_RS17055465736..466014-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
ASZ79_RS17060466011..466295-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ79_RS17065466489..467004+516WP_000343779.1GNAT family N-acetyltransferase-
ASZ79_RS17070467188..467601+414WP_000049420.1VOC family protein-
ASZ79_RS17085468156..469333+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..468464163764
insideIntegron--309780..468088158308
flankIS/Tn--461036..461473437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58369 WP_001114075.1 NZ_CP013314:463743-464012 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58369 NZ_CP013314:463743-464012 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT58369 WP_000921691.1 NZ_CP013314:464006-464527 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT58369 NZ_CP013314:464006-464527 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References