Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 361538..362078 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag ASZ80_RS16060 Protein ID WP_000277238.1
Coordinates 361538..361807 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag ASZ80_RS16065 Protein ID WP_001258569.1
Coordinates 361800..362078 (-) Length 93 a.a.

Genomic Context

ASZ80_RS16010ASZ80_RS16015ASZ80_RS16020ASZ80_RS16030ASZ80_RS16035ASZ80_RS20495ASZ80_RS20500ASZ80_RS16055ASZ80_RS16070ASZ80_RS20515ASZ80_RS20520ASZ80_RS16075ASZ80_RS16080ASZ80_RS16085ASZ80_RS16090ASZ80_RS16095ASZ80_RS20950ASZ80_RS20955ASZ80_RS16110ASZ80_RS16005ASZ80_RS16040ASZ80_RS16045ASZ80_RS16060ASZ80_RS16065
Location: 357028..357414 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 357471..357584 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 357533..357814 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 358072..358608 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 358745..359260 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 360569..360694 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 360710..360748 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 360944..361390 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 362364..362642 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 362894..363100 (207 bp)
Type: Others
Protein ID: Protein_348
Location: 363300..363401 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 363391..363777 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 363972..364223 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 364196..364345 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 364437..364679 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 364931..365209 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 365584..365727 (144 bp)
Type: Others
Protein ID: Protein_355
Location: 365781..365819 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 366031..366498 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 356542..356784 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 359410..359907 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 359904..360176 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 361538..361807 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 361800..362078 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ80_RS16005356542..356784-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ80_RS16010357028..357414+387WP_001015867.1NUDIX hydrolase-
ASZ80_RS16015357471..357584+114WP_001900214.1hypothetical protein-
ASZ80_RS16020357533..357814+282WP_001894429.1DUF1289 domain-containing protein-
ASZ80_RS16030358072..358608+537WP_000469482.1GNAT family N-acetyltransferase-
ASZ80_RS16035358745..359260+516WP_001201509.1lipocalin family protein-
ASZ80_RS16040359410..359907-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ80_RS16045359904..360176-273WP_000246253.1DUF1778 domain-containing protein-
ASZ80_RS20495360569..360694+126WP_001900195.1DUF645 family protein-
ASZ80_RS20500360710..360748+39WP_106019118.1hypothetical protein-
ASZ80_RS16055360944..361390+447WP_000006157.1hypothetical protein-
ASZ80_RS16060361538..361807-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
ASZ80_RS16065361800..362078-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
ASZ80_RS16070362364..362642+279WP_001921601.1DUF3709 domain-containing protein-
ASZ80_RS20515362894..363100+207Protein_348DUF3709 domain-containing protein-
ASZ80_RS20520363300..363401+102WP_001921603.1hypothetical protein-
ASZ80_RS16075363391..363777+387WP_000703163.1VOC family protein-
ASZ80_RS16080363972..364223+252WP_001890111.1TIGR03643 family protein-
ASZ80_RS16085364196..364345+150WP_071908333.1DUF3265 domain-containing protein-
ASZ80_RS16090364437..364679+243WP_000107461.1hypothetical protein-
ASZ80_RS16095364931..365209+279WP_000280324.1DUF3709 domain-containing protein-
ASZ80_RS20950365584..365727+144Protein_355DUF645 family protein-
ASZ80_RS20955365781..365819+39WP_082798268.1hypothetical protein-
ASZ80_RS16110366031..366498+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304694..469286164592
insideIntegron--309774..468910159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T58220 WP_000277238.1 NZ_CP013302:c361807-361538 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T58220 NZ_CP013302:c361807-361538 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT58220 WP_001258569.1 NZ_CP013302:c362078-361800 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT58220 NZ_CP013302:c362078-361800 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References