58220

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 361538..362078 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag ASZ80_RS16060 Protein ID WP_000277238.1
Coordinates 361538..361807 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag ASZ80_RS16065 Protein ID WP_001258569.1
Coordinates 361800..362078 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ80_RS16005 356542..356784 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ80_RS16010 357028..357414 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ80_RS16015 357471..357584 + 114 WP_001900214.1 hypothetical protein -
ASZ80_RS16020 357533..357814 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ80_RS16030 358072..358608 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ80_RS16035 358745..359260 + 516 WP_001201509.1 lipocalin family protein -
ASZ80_RS16040 359410..359907 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ80_RS16045 359904..360176 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ80_RS20495 360569..360694 + 126 WP_001900195.1 DUF645 family protein -
ASZ80_RS20500 360710..360748 + 39 WP_106019118.1 hypothetical protein -
ASZ80_RS16055 360944..361390 + 447 WP_000006157.1 hypothetical protein -
ASZ80_RS16060 361538..361807 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
ASZ80_RS16065 361800..362078 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ80_RS16070 362364..362642 + 279 WP_001921601.1 DUF3709 domain-containing protein -
ASZ80_RS20515 362894..363100 + 207 Protein_348 DUF3709 domain-containing protein -
ASZ80_RS20520 363300..363401 + 102 WP_001921603.1 hypothetical protein -
ASZ80_RS16075 363391..363777 + 387 WP_000703163.1 VOC family protein -
ASZ80_RS16080 363972..364223 + 252 WP_001890111.1 TIGR03643 family protein -
ASZ80_RS16085 364196..364345 + 150 WP_071908333.1 DUF3265 domain-containing protein -
ASZ80_RS16090 364437..364679 + 243 WP_000107461.1 hypothetical protein -
ASZ80_RS16095 364931..365209 + 279 WP_000280324.1 DUF3709 domain-containing protein -
ASZ80_RS20950 365584..365727 + 144 Protein_355 DUF645 family protein -
ASZ80_RS20955 365781..365819 + 39 WP_082798268.1 hypothetical protein -
ASZ80_RS16110 366031..366498 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304694..469286 164592
inside Integron - - 309774..468910 159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T58220 WP_000277238.1 NZ_CP013302:c361807-361538 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T58220 NZ_CP013302:c361807-361538 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT58220 WP_001258569.1 NZ_CP013302:c362078-361800 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT58220 NZ_CP013302:c362078-361800 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References