58358

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 382328..382866 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ79_RS16220 Protein ID WP_000802136.1
Coordinates 382328..382627 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ79_RS16225 Protein ID WP_001107719.1
Coordinates 382624..382866 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ79_RS16160 377523..378038 + 516 WP_001201520.1 lipocalin family protein -
ASZ79_RS16165 378103..378699 + 597 WP_000255434.1 hypothetical protein -
ASZ79_RS16180 379091..379273 + 183 WP_000923182.1 DUF645 family protein -
ASZ79_RS16185 379473..379946 + 474 WP_001161076.1 GrpB family protein -
ASZ79_RS16190 379961..380053 + 93 WP_014378730.1 DUF3265 domain-containing protein -
ASZ79_RS16195 380095..380721 + 627 WP_000365424.1 LysE family translocator -
ASZ79_RS16210 381412..381591 + 180 WP_001883058.1 DUF645 family protein -
ASZ79_RS16215 381805..382200 + 396 WP_000870857.1 DUF3465 domain-containing protein -
ASZ79_RS16220 382328..382627 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ79_RS16225 382624..382866 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ASZ79_RS16230 383095..383673 + 579 WP_000110120.1 hypothetical protein -
ASZ79_RS16235 383695..383787 + 93 WP_014164112.1 DUF3265 domain-containing protein -
ASZ79_RS16245 384211..384894 + 684 WP_000877436.1 hypothetical protein -
ASZ79_RS16250 385108..385374 + 267 WP_000937852.1 hypothetical protein -
ASZ79_RS16255 385529..386128 + 600 WP_000429495.1 hypothetical protein -
ASZ79_RS16260 386409..387344 + 936 WP_000051985.1 restriction endonuclease -
ASZ79_RS16265 387310..387450 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..468464 163764
inside Integron - - 309780..468088 158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58358 WP_000802136.1 NZ_CP013314:c382627-382328 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58358 NZ_CP013314:c382627-382328 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58358 WP_001107719.1 NZ_CP013314:c382866-382624 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58358 NZ_CP013314:c382866-382624 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References