Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 225675..226173 Replicon chromosome
Accession NZ_LT992493
Organism Vibrio cholerae strain 4295STDY6534248

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag DG169_RS15540 Protein ID WP_000589156.1
Coordinates 225675..225941 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag DG169_RS15545 Protein ID WP_000643598.1
Coordinates 225928..226173 (+) Length 82 a.a.

Genomic Context

DG169_RS15480DG169_RS15485DG169_RS15490DG169_RS15495DG169_RS15500DG169_RS15505DG169_RS15510DG169_RS19815DG169_RS19820DG169_RS15525DG169_RS15530DG169_RS15540DG169_RS15545DG169_RS15550DG169_RS19825DG169_RS15565DG169_RS15570DG169_RS15575DG169_RS15580DG169_RS15585DG169_RS15590DG169_RS15605
Location: 221096..221302 (207 bp)
Type: Others
Protein ID: Protein_208
Location: 221502..221603 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 221593..221979 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 222174..222425 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 222398..222547 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 222639..222881 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 223133..223411 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 223786..223929 (144 bp)
Type: Others
Protein ID: Protein_215
Location: 223983..224021 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 224233..224700 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 224828..225490 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 225675..225941 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 225928..226173 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 226269..227063 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 227166..227294 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 227355..227537 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 227737..228210 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 228225..228317 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 228359..228985 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 229108..229806 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 229816..229926 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 230504..230683 (180 bp)
Type: Others
Protein ID: WP_001883058.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG169_RS15480221096..221302+207Protein_208DUF3709 domain-containing protein-
DG169_RS15485221502..221603+102WP_001921603.1hypothetical protein-
DG169_RS15490221593..221979+387WP_000703163.1VOC family protein-
DG169_RS15495222174..222425+252WP_001890111.1TIGR03643 family protein-
DG169_RS15500222398..222547+150WP_071908333.1DUF3265 domain-containing protein-
DG169_RS15505222639..222881+243WP_000107461.1hypothetical protein-
DG169_RS15510223133..223411+279WP_000280324.1DUF3709 domain-containing protein-
DG169_RS19815223786..223929+144Protein_215DUF645 family protein-
DG169_RS19820223983..224021+39WP_082798268.1hypothetical protein-
DG169_RS15525224233..224700+468WP_001289288.1OsmC family protein-
DG169_RS15530224828..225490+663WP_000960654.1hypothetical protein-
DG169_RS15540225675..225941+267WP_000589156.1BrnT family toxinToxin
DG169_RS15545225928..226173+246WP_000643598.1hypothetical proteinAntitoxin
DG169_RS15550226269..227063+795WP_001911581.1hypothetical protein-
DG169_RS19825227166..227294+129WP_071908338.1general secretion pathway protein GspI-
DG169_RS15565227355..227537+183WP_000923182.1DUF645 family protein-
DG169_RS15570227737..228210+474WP_001161076.1GrpB family protein-
DG169_RS15575228225..228317+93WP_014378730.1DUF3265 domain-containing protein-
DG169_RS15580228359..228985+627WP_000365424.1LysE family translocator-
DG169_RS15585229108..229806+699WP_001890502.1hypothetical protein-
DG169_RS15590229816..229926+111WP_079857360.1DUF3265 domain-containing protein-
DG169_RS15605230504..230683+180WP_001883058.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-197768..29303295264
insideIntegroncatB9-202848..29265689808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T294409 WP_000589156.1 NZ_LT992493:225675-225941 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT294409 WP_000643598.1 NZ_LT992493:225928-226173 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References