145070

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 394804..395344 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag GPY07_RS16420 Protein ID WP_000277238.1
Coordinates 395075..395344 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag GPY07_RS16415 Protein ID WP_001258569.1
Coordinates 394804..395082 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY07_RS16365 390384..390851 - 468 WP_001289288.1 OsmC family protein -
GPY07_RS19460 391063..391101 - 39 WP_082798268.1 hypothetical protein -
GPY07_RS19465 391155..391298 - 144 Protein_400 DUF645 family protein -
GPY07_RS16375 391673..391951 - 279 WP_000280324.1 DUF3709 domain-containing protein -
GPY07_RS16380 392203..392445 - 243 WP_000107461.1 hypothetical protein -
GPY07_RS16385 392537..392686 - 150 WP_071908333.1 DUF3265 domain-containing protein -
GPY07_RS16390 392659..392910 - 252 WP_001890111.1 TIGR03643 family protein -
GPY07_RS16395 393105..393491 - 387 WP_000703163.1 VOC family protein -
GPY07_RS16400 393481..393582 - 102 WP_001921603.1 hypothetical protein -
GPY07_RS16405 393782..393988 - 207 Protein_407 DUF3709 domain-containing protein -
GPY07_RS16410 394240..394518 - 279 WP_001921601.1 DUF3709 domain-containing protein -
GPY07_RS16415 394804..395082 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPY07_RS16420 395075..395344 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
GPY07_RS16425 395492..395938 - 447 WP_000006157.1 hypothetical protein -
GPY07_RS16435 396134..396172 - 39 WP_106019118.1 hypothetical protein -
GPY07_RS16440 396188..396313 - 126 WP_001900195.1 DUF645 family protein -
GPY07_RS16445 396706..396978 + 273 WP_000246253.1 DUF1778 domain-containing protein -
GPY07_RS16450 396975..397472 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
GPY07_RS16455 397622..398137 - 516 WP_001201509.1 lipocalin family protein -
GPY07_RS16460 398274..398810 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
GPY07_RS16470 399068..399349 - 282 WP_001894429.1 DUF1289 domain-containing protein -
GPY07_RS16475 399298..399411 - 114 WP_001900214.1 hypothetical protein -
GPY07_RS16480 399468..399854 - 387 WP_001015867.1 NUDIX hydrolase -
GPY07_RS16485 400098..400340 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 322056..419024 96968
inside Integron - - 322432..412236 89804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T145070 WP_000277238.1 NZ_CP046841:395075-395344 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T145070 NZ_CP062253:c2914599-2913532 [Pseudomonas gozinkensis]
ATGAACCTCGAAAAAATCAAGGGACGCCTCGACTTCCTGCGCGAAGCGGAACGGCTCAAGGATGTCCTCAGAAGCGCCCA
CACCTCCTCCGGACGCAGCGAAAGTACCGCCGAACACAGCTGGCGCCTGTGCCTGATGGCAATCGTGTTCGCCGACGACC
TGGCCGGGCTTGACGTGCTGAAAGTCCTGAAAATGTGCGTCATTCACGACCTCGGCGAAGCCATCAACGGTGACATTCCA
GCTGTCGATCAAGCCGGGTTACCCGACAAGGGCGAACAGGAGCGCAATGACTTACTGCTGCTCATCCGCTCTCTGGACGA
CGCGCTGCGAGACGAAATTCTCGCGCTCTGGGACGACTACGAAAACGCCAGTTCCCCCGAAGCCAAGGCCGTGAAGGCCC
TCGACAAGCTGGAAACCCTTTTACAACACACTCAAGGGAAGAATCCGCCCGACTTCGACTATGGCTTCAACCTGGCCTAC
GGCAAGCAATACACCAATGCCGATCCGCTGTTCGAAACCCTTCGAACCCTGATCGACCGCGATACCCGAGAACGCATGAA
CACAAACATCACAATCCGCAACGAACGCCCCGAAGACATCGACGCCATCGCCCGAATCACCGAGGCCGCGTTCCAGCACG
AAGAACACTCCAGCCACACCGAACATTTCATCGTCAACGCCCTGCGCCGCGCCGGCCAGCTCAGCGTTTCGCTGGTGGCG
GTAGAAAACGACACGGTGGTCGGCCATGTCGCCATTTCCCCCGTGACGATTTCCTCCGGGGCTCAGGGCTGGTATGGCCT
CGGCCCGATCTCCGTGTGCCCGACCCGCCAGCAGCAAGGCATCGGCTCGGCGCTGATGAAAGCCTCGCTGGCGCAATTGC
AGCGCATTGGCGGGGTTGGCTGCGTGGTGCTTGGCGATCCGGGCTACTACGGCCGCTTCGGCTTCAAGACCCATGCCGGT
CTGGAGCTGCCGGGGATTCCGGCGGAGTACTTTCAGGCGTTGGCGTTCGAAGGTGAGTTGCCGGTTGGTGTCGTCAGCTA
CCACGAGGCTTTTGACGCCACCGCGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT145070 WP_001258569.1 NZ_CP046841:394804-395082 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT145070 NZ_CP062253:c2915242-2914685 [Pseudomonas gozinkensis]
ATGTCCGACACCTTGTTGAAGCCCAGCCTGCCCGGCATCGCCCTGCGCCGCTGGCGCGTGCTGCACCGCGTCAAGCAGAG
CCATGCCGCCGAGTTGTTCAAGGTCACCCAGTCGACGATTTCCCGCTGGGAAAGCGGCGTGCAGGCGATGGACCCGGACG
CGCATCTTCAGCTCGAACGGCTGCTCGCGGCGCGACTCGACAGCGCCGCCGATCAGGCCCTCGCGCGACTGGTTACGGAC
AGCGCGCGCCCGGTTCATCTTGTCTGCGACCTGACCCATCGCCTGCTGGCCTGCTCCCCAACCCGCGCCGCGCAGTTCAG
CAGTCCGCTGAGCGATCTGCTCGGGCAGTCGCTGTGGCGTTTTGCGACGGCGCAAATCCAGCACAAGGAGTCCTTGCTGG
ATGACACCGGTTGGCGAGAAGTCCCGGCGCCGCCGGCACTGGAATTCGTCACCGGCCACAATGACTCAACCCTCGTGCCC
ATCCGCGAAAGCCTGTGCCGCTGGACGCGGATCGCGCTGTCGGACGGCACCGCCGCACGGCTGGTGGAAACCCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References