Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 834685..835223 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag A6J62_RS04235 Protein ID WP_000802136.1
Coordinates 834924..835223 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag A6J62_RS04230 Protein ID WP_001107719.1
Coordinates 834685..834927 (+) Length 81 a.a.

Genomic Context

A6J62_RS04230A6J62_RS04235A6J62_RS04175A6J62_RS04180A6J62_RS04185A6J62_RS04195A6J62_RS04205A6J62_RS04215A6J62_RS04220A6J62_RS04240A6J62_RS04245A6J62_RS04260A6J62_RS04265A6J62_RS04270A6J62_RS04275A6J62_RS04280A6J62_RS04285
Location: 834685..834927 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
Location: 834924..835223 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 830101..830241 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 830207..831142 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 831423..832022 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 832177..832443 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 832657..833340 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 833764..833856 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 833878..834456 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 835351..835746 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 835960..836139 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 836717..836827 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 836837..837535 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 837658..838284 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 838326..838418 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 838433..838906 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 839106..839288 (183 bp)
Type: Others
Protein ID: WP_000923182.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A6J62_RS04175830101..830241-141WP_001883049.1DUF3265 domain-containing protein-
A6J62_RS04180830207..831142-936WP_000051985.1restriction endonuclease-
A6J62_RS04185831423..832022-600WP_000429495.1hypothetical protein-
A6J62_RS04195832177..832443-267WP_000937852.1hypothetical protein-
A6J62_RS04205832657..833340-684WP_000877436.1hypothetical protein-
A6J62_RS04215833764..833856-93WP_014164112.1DUF3265 domain-containing protein-
A6J62_RS04220833878..834456-579WP_000110120.1hypothetical protein-
A6J62_RS04230834685..834927+243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
A6J62_RS04235834924..835223+300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
A6J62_RS04240835351..835746-396WP_000870857.1DUF3465 domain-containing protein-
A6J62_RS04245835960..836139-180WP_001883058.1DUF645 family protein-
A6J62_RS04260836717..836827-111WP_079857360.1DUF3265 domain-containing protein-
A6J62_RS04265836837..837535-699WP_001890502.1hypothetical protein-
A6J62_RS04270837658..838284-627WP_000365424.1LysE family translocator-
A6J62_RS04275838326..838418-93WP_014378730.1DUF3265 domain-containing protein-
A6J62_RS04280838433..838906-474WP_001161076.1GrpB family protein-
A6J62_RS04285839106..839288-183WP_000923182.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-749087..881909132822
insideIntegron--749463..875103125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T74626 WP_000802136.1 NZ_CP020407:834924-835223 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T74626 NZ_CP020407:834924-835223 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT74626 WP_001107719.1 NZ_CP020407:834685-834927 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT74626 NZ_CP020407:834685-834927 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References