74626

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 834685..835223 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag A6J62_RS04235 Protein ID WP_000802136.1
Coordinates 834924..835223 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag A6J62_RS04230 Protein ID WP_001107719.1
Coordinates 834685..834927 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J62_RS04175 830101..830241 - 141 WP_001883049.1 DUF3265 domain-containing protein -
A6J62_RS04180 830207..831142 - 936 WP_000051985.1 restriction endonuclease -
A6J62_RS04185 831423..832022 - 600 WP_000429495.1 hypothetical protein -
A6J62_RS04195 832177..832443 - 267 WP_000937852.1 hypothetical protein -
A6J62_RS04205 832657..833340 - 684 WP_000877436.1 hypothetical protein -
A6J62_RS04215 833764..833856 - 93 WP_014164112.1 DUF3265 domain-containing protein -
A6J62_RS04220 833878..834456 - 579 WP_000110120.1 hypothetical protein -
A6J62_RS04230 834685..834927 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
A6J62_RS04235 834924..835223 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6J62_RS04240 835351..835746 - 396 WP_000870857.1 DUF3465 domain-containing protein -
A6J62_RS04245 835960..836139 - 180 WP_001883058.1 DUF645 family protein -
A6J62_RS04260 836717..836827 - 111 WP_079857360.1 DUF3265 domain-containing protein -
A6J62_RS04265 836837..837535 - 699 WP_001890502.1 hypothetical protein -
A6J62_RS04270 837658..838284 - 627 WP_000365424.1 LysE family translocator -
A6J62_RS04275 838326..838418 - 93 WP_014378730.1 DUF3265 domain-containing protein -
A6J62_RS04280 838433..838906 - 474 WP_001161076.1 GrpB family protein -
A6J62_RS04285 839106..839288 - 183 WP_000923182.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 749087..881909 132822
inside Integron - - 749463..875103 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T74626 WP_000802136.1 NZ_CP020407:834924-835223 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T74626 NZ_CP020407:834924-835223 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT74626 WP_001107719.1 NZ_CP020407:834685-834927 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT74626 NZ_CP020407:834685-834927 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References