Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 342237..342870 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag GPY07_RS15915 Protein ID WP_000843587.1
Coordinates 342538..342870 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GPY07_RS15910 Protein ID WP_000071008.1
Coordinates 342237..342551 (-) Length 105 a.a.

Genomic Context

GPY07_RS15895GPY07_RS15860GPY07_RS15865GPY07_RS15870GPY07_RS15875GPY07_RS15880GPY07_RS15885GPY07_RS15890GPY07_RS15900GPY07_RS15905GPY07_RS15910GPY07_RS15915GPY07_RS15925GPY07_RS15930GPY07_RS15940GPY07_RS19435GPY07_RS15945GPY07_RS15950GPY07_RS15955GPY07_RS15960GPY07_RS15965GPY07_RS15970GPY07_RS19440
Location: 340238..341218 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 337291..337578 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 337568..337819 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 338033..338446 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 338521..338664 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 338634..339035 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 339035..339727 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 339864..340170 (307 bp)
Type: Others
Protein ID: Protein_310
Location: 341343..341498 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 341666..342100 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 342237..342551 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 342538..342870 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 343211..343438 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 343387..343500 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 343666..343947 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 343896..344010 (115 bp)
Type: Others
Protein ID: Protein_319
Location: 344067..344444 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 344615..344857 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 345059..345445 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 345654..345825 (172 bp)
Type: Others
Protein ID: Protein_323
Location: 346143..346412 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 346772..346945 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 347226..347429 (204 bp)
Type: Others
Protein ID: WP_001911745.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY07_RS15860337291..337578-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY07_RS15865337568..337819-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GPY07_RS15870338033..338446-414WP_000049417.1VOC family protein-
GPY07_RS15875338521..338664-144WP_071908341.1DUF3265 domain-containing protein-
GPY07_RS15880338634..339035-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
GPY07_RS15885339035..339727-693WP_001047169.1GNAT family N-acetyltransferase-
GPY07_RS15890339864..340170-307Protein_310CatB-related O-acetyltransferase-
GPY07_RS15895340238..341218+981WP_000019370.1IS5-like element ISVch5 family transposase-
GPY07_RS15900341343..341498-156WP_000751734.1hypothetical protein-
GPY07_RS15905341666..342100-435WP_000256036.1GNAT family N-acetyltransferase-
GPY07_RS15910342237..342551-315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
GPY07_RS15915342538..342870-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GPY07_RS15925343211..343438-228WP_001894457.1DUF1289 domain-containing protein-
GPY07_RS15930343387..343500-114WP_001889158.1hypothetical protein-
GPY07_RS15940343666..343947-282WP_001894453.1DUF1289 domain-containing protein-
GPY07_RS19435343896..344010-115Protein_319acetyltransferase-
GPY07_RS15945344067..344444-378WP_000411109.1hypothetical protein-
GPY07_RS15950344615..344857-243WP_000107461.1hypothetical protein-
GPY07_RS15955345059..345445-387WP_000703163.1VOC family protein-
GPY07_RS15960345654..345825-172Protein_323DUF645 family protein-
GPY07_RS15965346143..346412-270WP_001198131.1hypothetical protein-
GPY07_RS15970346772..346945-174WP_001882305.1DUF3709 domain-containing protein-
GPY07_RS19440347226..347429-204WP_001911745.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-322056..41902496968
insideIntegron--322432..41223689804
flankIS/Tn--340238..341218980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T145064 WP_000843587.1 NZ_CP046841:c342870-342538 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T145064 NZ_CP062252:4184492-4184836 [Pseudomonas allokribbensis]
ATGGATGCTCTTTTTATCGAATTACCCGCGTTCCAGAAGCACCGGGACGATTACCTGGATGATGATTTGTTCCGCAGCTT
TCAATTAGAGCTGCTGAAAAATCCCGAAGCGGGCGATCTCATCGAAGGAACGGGTGGGCTGCGTAAAATTCGCTTCTGCG
ACCAACGACGCGGTAAAGGCAAGCGCAGCGGATTACGAGTGATTTATTACTGGTGGTCTGGTTTCGACCAATTCTGGCTG
TTCACCGTGTACAGCAAAAACGAGCAAGACGATCTGTTGCCTTCCCAGAAAAGAGTCTTCAAACAGGCTCTGGATACAGA
AATCAACACGAGAACCCAAATATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT145064 WP_000071008.1 NZ_CP046841:c342551-342237 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT145064 NZ_CP062252:4184833-4185147 [Pseudomonas allokribbensis]
ATGAAACGTGACATTTTTTCCGAACTGATGGAGGGCCTTGAGGCTTTGGCCGACGAGCGCCAGGGCAAGGTCACCCTTCG
CACCCACAAAGTCCAGTTACCAAAACTATTGCCGATCACTGCCGAGGAAGTTGTTGCGATCCGCCAGCAACTCAACCTCT
CCCGGTCAGTTTTCGCCATGTACCTGCGAACCAACACTCGAACCCTCGAAAACTGGGAACAAGGTCGAGCAACGCCAAAT
GCCCAAGCGACGACACTCATTCGACTGGTCGAGCGTTTTCCACAAACGATCGACCACCTTGCGGCTCTGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References