145064

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 342237..342870 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag GPY07_RS15915 Protein ID WP_000843587.1
Coordinates 342538..342870 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GPY07_RS15910 Protein ID WP_000071008.1
Coordinates 342237..342551 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY07_RS15860 337291..337578 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPY07_RS15865 337568..337819 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPY07_RS15870 338033..338446 - 414 WP_000049417.1 VOC family protein -
GPY07_RS15875 338521..338664 - 144 WP_071908341.1 DUF3265 domain-containing protein -
GPY07_RS15880 338634..339035 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GPY07_RS15885 339035..339727 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
GPY07_RS15890 339864..340170 - 307 Protein_310 CatB-related O-acetyltransferase -
GPY07_RS15895 340238..341218 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
GPY07_RS15900 341343..341498 - 156 WP_000751734.1 hypothetical protein -
GPY07_RS15905 341666..342100 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
GPY07_RS15910 342237..342551 - 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
GPY07_RS15915 342538..342870 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY07_RS15925 343211..343438 - 228 WP_001894457.1 DUF1289 domain-containing protein -
GPY07_RS15930 343387..343500 - 114 WP_001889158.1 hypothetical protein -
GPY07_RS15940 343666..343947 - 282 WP_001894453.1 DUF1289 domain-containing protein -
GPY07_RS19435 343896..344010 - 115 Protein_319 acetyltransferase -
GPY07_RS15945 344067..344444 - 378 WP_000411109.1 hypothetical protein -
GPY07_RS15950 344615..344857 - 243 WP_000107461.1 hypothetical protein -
GPY07_RS15955 345059..345445 - 387 WP_000703163.1 VOC family protein -
GPY07_RS15960 345654..345825 - 172 Protein_323 DUF645 family protein -
GPY07_RS15965 346143..346412 - 270 WP_001198131.1 hypothetical protein -
GPY07_RS15970 346772..346945 - 174 WP_001882305.1 DUF3709 domain-containing protein -
GPY07_RS19440 347226..347429 - 204 WP_001911745.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 322056..419024 96968
inside Integron - - 322432..412236 89804
flank IS/Tn - - 340238..341218 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T145064 WP_000843587.1 NZ_CP046841:c342870-342538 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T145064 NZ_CP062252:4184492-4184836 [Pseudomonas allokribbensis]
ATGGATGCTCTTTTTATCGAATTACCCGCGTTCCAGAAGCACCGGGACGATTACCTGGATGATGATTTGTTCCGCAGCTT
TCAATTAGAGCTGCTGAAAAATCCCGAAGCGGGCGATCTCATCGAAGGAACGGGTGGGCTGCGTAAAATTCGCTTCTGCG
ACCAACGACGCGGTAAAGGCAAGCGCAGCGGATTACGAGTGATTTATTACTGGTGGTCTGGTTTCGACCAATTCTGGCTG
TTCACCGTGTACAGCAAAAACGAGCAAGACGATCTGTTGCCTTCCCAGAAAAGAGTCTTCAAACAGGCTCTGGATACAGA
AATCAACACGAGAACCCAAATATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT145064 WP_000071008.1 NZ_CP046841:c342551-342237 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT145064 NZ_CP062252:4184833-4185147 [Pseudomonas allokribbensis]
ATGAAACGTGACATTTTTTCCGAACTGATGGAGGGCCTTGAGGCTTTGGCCGACGAGCGCCAGGGCAAGGTCACCCTTCG
CACCCACAAAGTCCAGTTACCAAAACTATTGCCGATCACTGCCGAGGAAGTTGTTGCGATCCGCCAGCAACTCAACCTCT
CCCGGTCAGTTTTCGCCATGTACCTGCGAACCAACACTCGAACCCTCGAAAACTGGGAACAAGGTCGAGCAACGCCAAAT
GCCCAAGCGACGACACTCATTCGACTGGTCGAGCGTTTTCCACAAACGATCGACCACCTTGCGGCTCTGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References