Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 431441..432225 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GTF73_RS16170 Protein ID WP_001114075.1
Coordinates 431441..431710 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag GTF73_RS16175 Protein ID WP_000921691.1
Coordinates 431704..432225 (+) Length 174 a.a.

Genomic Context

GTF73_RS16130GTF73_RS16135GTF73_RS16140GTF73_RS16145GTF73_RS16150GTF73_RS16155GTF73_RS16160GTF73_RS16165GTF73_RS16170GTF73_RS16175GTF73_RS16180GTF73_RS16185GTF73_RS16200GTF73_RS16205GTF73_RS16210GTF73_RS16220GTF73_RS16190GTF73_RS16195GTF73_RS16215
Location: 426807..427724 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427881..428270 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428406..428615 (210 bp)
Type: Others
Protein ID: Protein_471
Location: 428734..429171 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 429235..429453 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429628..430500 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430650..431249 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 431306..431410 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 431441..431710 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 431704..432225 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 432524..432649 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 432900..433295 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 434187..434702 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 434759..434854 (96 bp)
Type: Others
Protein ID: WP_099607151.1
Location: 434886..435299 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 435854..437031 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 433434..433712 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 433709..433993 (285 bp)
Type: Others
Protein ID: WP_000381183.1
Location: 435306..435438 (133 bp)
Type: Others
Protein ID: Protein_486
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF73_RS16130426807..427724+918WP_000186333.1alpha/beta hydrolase-
GTF73_RS16135427881..428270+390WP_001081302.1hypothetical protein-
GTF73_RS16140428406..428615+210Protein_471GNAT family N-acetyltransferase-
GTF73_RS16145428734..429171+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
GTF73_RS16150429235..429453+219WP_071908318.1GNAT family N-acetyltransferase-
GTF73_RS16155429628..430500+873WP_000254716.1DUF3800 domain-containing protein-
GTF73_RS16160430650..431249+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
GTF73_RS16165431306..431410+105WP_099607150.1acetyltransferase-
GTF73_RS16170431441..431710+270WP_001114075.1DUF4160 domain-containing proteinToxin
GTF73_RS16175431704..432225+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
GTF73_RS16180432524..432649+126WP_001905700.1DUF645 family protein-
GTF73_RS16185432900..433295+396WP_001000867.1hypothetical protein-
GTF73_RS16190433434..433712-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
GTF73_RS16195433709..433993-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
GTF73_RS16200434187..434702+516WP_000343779.1GNAT family N-acetyltransferase-
GTF73_RS16205434759..434854+96WP_099607151.1acetyltransferase-
GTF73_RS16210434886..435299+414WP_000049420.1VOC family protein-
GTF73_RS16215435306..435438-133Protein_486hypothetical protein-
GTF73_RS16220435854..437031+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306901..436162129261
insideIntegron--311981..435786123805
flankIS/Tn--428734..429171437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T145840 WP_001114075.1 NZ_CP047298:431441-431710 [Vibrio cholerae O1 biovar El Tor]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T145840 NZ_CP062702:2288914-2289017 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT145840 WP_000921691.1 NZ_CP047298:431704-432225 [Vibrio cholerae O1 biovar El Tor]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT145840 NZ_CP062702:c2289055-2288784 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References