Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 399293..399821 Replicon chromosome
Accession NZ_LT907990
Organism Vibrio cholerae strain A19

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag ALC86_RS16225 Protein ID WP_000221352.1
Coordinates 399293..399583 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag ALC86_RS16230 Protein ID WP_000213183.1
Coordinates 399573..399821 (-) Length 83 a.a.

Genomic Context

ALC86_RS19750ALC86_RS19755ALC86_RS16195ALC86_RS16200ALC86_RS16205ALC86_RS16210ALC86_RS16215ALC86_RS16220ALC86_RS16240ALC86_RS16245ALC86_RS16250ALC86_RS16255ALC86_RS16260ALC86_RS16270ALC86_RS16225ALC86_RS16230ALC86_RS16275
Location: 394850..394975 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 394991..395029 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 395242..396246 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 396399..396845 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 396965..397894 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 397891..398001 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 398029..398505 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 398642..399157 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 400392..401045 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 401317..401742 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 401950..402345 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 402496..403026 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 403164..403664 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 403820..404218 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 399293..399583 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 399573..399821 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 404318..404782 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ALC86_RS19750394850..394975+126WP_001944767.1DUF645 family protein-
ALC86_RS19755394991..395029+39WP_106019119.1hypothetical protein-
ALC86_RS16195395242..396246+1005WP_000964925.1LD-carboxypeptidase-
ALC86_RS16200396399..396845+447WP_000128977.1hypothetical protein-
ALC86_RS16205396965..397894+930WP_000335802.1hypothetical protein-
ALC86_RS16210397891..398001+111WP_071917832.1DUF3265 domain-containing protein-
ALC86_RS16215398029..398505+477WP_001047180.1GNAT family N-acetyltransferase-
ALC86_RS16220398642..399157+516WP_001201528.1lipocalin family protein-
ALC86_RS16225399293..399583-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ALC86_RS16230399573..399821-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ALC86_RS16240400392..401045+654WP_000036957.1site-specific DNA-methyltransferase-
ALC86_RS16245401317..401742+426WP_000415748.1hypothetical protein-
ALC86_RS16250401950..402345+396WP_000649527.1DUF3465 domain-containing protein-
ALC86_RS16255402496..403026+531WP_000415563.1hypothetical protein-
ALC86_RS16260403164..403664+501WP_000789723.1hypothetical protein-
ALC86_RS16270403820..404218+399WP_001882293.1hypothetical protein-
ALC86_RS16275404318..404782-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T293829 WP_000221352.1 NZ_LT907990:c399583-399293 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT293829 WP_000213183.1 NZ_LT907990:c399821-399573 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References