Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 214912..215471 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag K6J80_RS14800 Protein ID WP_000578476.1
Coordinates 215193..215471 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag K6J80_RS14795 Protein ID WP_000381183.1
Coordinates 214912..215196 (+) Length 95 a.a.

Genomic Context

K6J80_RS14795K6J80_RS14800K6J80_RS14785K6J80_RS14790K6J80_RS14805K6J80_RS14810K6J80_RS14815K6J80_RS14820K6J80_RS14825K6J80_RS14830K6J80_RS14835K6J80_RS14840K6J80_RS14845
Location: 214912..215196 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 215193..215471 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 213606..214019 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 214203..214718 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 215610..216005 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 216256..216381 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 216680..217201 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 217195..217464 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 217531..217599 (69 bp)
Type: Others
Protein ID: Protein_190
Location: 217656..218255 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 218405..219277 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 219452..219673 (222 bp)
Type: Others
Protein ID: Protein_193
Location: 219734..220171 (438 bp)
Type: Others
Protein ID: WP_000503169.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J80_RS14785213606..214019-414WP_000049420.1VOC family protein-
K6J80_RS14790214203..214718-516WP_000343779.1GNAT family protein-
K6J80_RS14795214912..215196+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
K6J80_RS14800215193..215471+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
K6J80_RS14805215610..216005-396WP_001000867.1hypothetical protein-
K6J80_RS14810216256..216381-126WP_001905700.1DUF645 family protein-
K6J80_RS14815216680..217201-522WP_000921691.1DUF2442 domain-containing protein-
K6J80_RS14820217195..217464-270WP_001114075.1DUF4160 domain-containing protein-
K6J80_RS14825217531..217599-69Protein_190acetyltransferase-
K6J80_RS14830217656..218255-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
K6J80_RS14835218405..219277-873WP_000254716.1DUF3800 domain-containing protein-
K6J80_RS14840219452..219673-222Protein_193GNAT family N-acetyltransferase-
K6J80_RS14845219734..220171-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-213119..319686106567
insideIntegron--213119..31285699737
flankIS/Tn--219734..220171437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T38668 WP_000578476.1 NZ_AP024554:215193-215471 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T38668 NZ_AP024554:215193-215471 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT38668 WP_000381183.1 NZ_AP024554:214912-215196 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT38668 NZ_AP024554:214912-215196 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References