180877

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 488488..489254 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag IT766_RS16290 Protein ID WP_000982260.1
Coordinates 488488..488985 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag IT766_RS16295 Protein ID WP_000246253.1
Coordinates 488982..489254 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT766_RS16245 484350..484622 + 273 Protein_499 CatB-related O-acetyltransferase -
IT766_RS16250 484793..485485 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
IT766_RS16255 485485..485886 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
IT766_RS16260 485856..485999 + 144 WP_071908341.1 DUF3265 domain-containing protein -
IT766_RS16265 486074..486487 + 414 WP_000049417.1 VOC family protein -
IT766_RS16270 486701..486952 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IT766_RS16275 486942..487229 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
IT766_RS16280 487357..487812 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
IT766_RS16285 488134..488286 + 153 WP_001884520.1 DUF645 family protein -
IT766_RS16290 488488..488985 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
IT766_RS16295 488982..489254 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
IT766_RS16300 489485..490153 + 669 WP_000043871.1 hypothetical protein -
IT766_RS16305 490305..490592 + 288 WP_000426470.1 hypothetical protein -
IT766_RS16310 490733..491104 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
IT766_RS16315 491171..491596 + 426 WP_001882332.1 DUF1778 domain-containing protein -
IT766_RS16320 491593..492126 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
IT766_RS16325 492328..492585 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IT766_RS16330 492573..492875 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
IT766_RS16335 493109..494026 + 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 373204..502464 129260
inside Integron - - 378284..502088 123804
flank IS/Tn - - 483302..484282 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T180877 WP_000982260.1 NZ_CP064351:c488985-488488 [Vibrio cholerae C6706]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T180877 NZ_CP085767:c3073032-3072814 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
AATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTGGCTGAAC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTTTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT180877 WP_000246253.1 NZ_CP064351:c489254-488982 [Vibrio cholerae C6706]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT180877 NZ_CP085767:c3073434-3073060 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTCAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References