145849

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 368879..369457 Replicon chromosome
Accession NZ_CP047300
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GTF71_RS15265 Protein ID WP_001180243.1
Coordinates 368879..369196 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GTF71_RS15270 Protein ID WP_000557292.1
Coordinates 369215..369457 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF71_RS15220 364109..364465 + 357 WP_001094969.1 hypothetical protein -
GTF71_RS15225 364768..364949 + 182 Protein_355 DUF645 family protein -
GTF71_RS15230 365126..365521 + 396 WP_000046953.1 hypothetical protein -
GTF71_RS15235 365665..366201 + 537 WP_000644491.1 nucleotidyltransferase family protein -
GTF71_RS15240 366498..366677 + 180 WP_001883039.1 DUF645 family protein -
GTF71_RS15245 366873..367298 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
GTF71_RS15250 367447..367794 + 348 WP_000933409.1 hypothetical protein -
GTF71_RS15255 367941..368234 + 294 WP_125460920.1 hypothetical protein -
GTF71_RS15260 368590..368685 + 96 WP_001907607.1 DUF645 family protein -
GTF71_RS15265 368879..369196 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF71_RS15270 369215..369457 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF71_RS15275 369699..370208 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
GTF71_RS15280 370265..370918 + 654 WP_000226874.1 hypothetical protein -
GTF71_RS15285 371228..371446 + 219 WP_001917086.1 DUF3709 domain-containing protein -
GTF71_RS15290 371849..372082 + 234 WP_032482776.1 DUF3709 domain-containing protein -
GTF71_RS15295 372507..372687 + 181 Protein_369 DUF645 family protein -
GTF71_RS15300 372954..373241 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTF71_RS15305 373252..373569 + 318 WP_001232701.1 HigA family addiction module antidote protein -
GTF71_RS15310 373566..373676 + 111 WP_134814058.1 DUF3265 domain-containing protein -
GTF71_RS15315 373853..373978 + 126 WP_001944767.1 DUF645 family protein -
GTF71_RS15320 373994..374032 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306926..439292 132366
inside Integron - - 312006..438916 126910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145849 WP_001180243.1 NZ_CP047300:c369196-368879 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145849 NZ_CP062702:c3588891-3588514 [Escherichia coli O157:H7]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCTGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGTGAAACAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145849 WP_000557292.1 NZ_CP047300:c369457-369215 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145849 NZ_CP062702:c3589349-3588981 [Escherichia coli O157:H7]
GTGTCAGACACGCTCCATGAAACAAATCACCCCGACGGCAATAACAACAGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGTATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCAAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References