Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 368879..369457 Replicon chromosome
Accession NZ_CP047300
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GTF71_RS15265 Protein ID WP_001180243.1
Coordinates 368879..369196 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GTF71_RS15270 Protein ID WP_000557292.1
Coordinates 369215..369457 (-) Length 81 a.a.

Genomic Context

GTF71_RS15220GTF71_RS15225GTF71_RS15230GTF71_RS15235GTF71_RS15240GTF71_RS15245GTF71_RS15250GTF71_RS15255GTF71_RS15260GTF71_RS15275GTF71_RS15280GTF71_RS15285GTF71_RS15290GTF71_RS15295GTF71_RS15300GTF71_RS15305GTF71_RS15310GTF71_RS15315GTF71_RS15320GTF71_RS15265GTF71_RS15270
Location: 364109..364465 (357 bp)
Type: Others
Protein ID: WP_001094969.1
Location: 364768..364949 (182 bp)
Type: Others
Protein ID: Protein_355
Location: 365126..365521 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 365665..366201 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 366498..366677 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 366873..367298 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 367447..367794 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 367941..368234 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 368590..368685 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 369699..370208 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 370265..370918 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 371228..371446 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 371849..372082 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 372507..372687 (181 bp)
Type: Others
Protein ID: Protein_369
Location: 372954..373241 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 373252..373569 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 373566..373676 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 373853..373978 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 373994..374032 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 368879..369196 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 369215..369457 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF71_RS15220364109..364465+357WP_001094969.1hypothetical protein-
GTF71_RS15225364768..364949+182Protein_355DUF645 family protein-
GTF71_RS15230365126..365521+396WP_000046953.1hypothetical protein-
GTF71_RS15235365665..366201+537WP_000644491.1nucleotidyltransferase family protein-
GTF71_RS15240366498..366677+180WP_001883039.1DUF645 family protein-
GTF71_RS15245366873..367298+426WP_000403014.1GNAT family N-acetyltransferase-
GTF71_RS15250367447..367794+348WP_000933409.1hypothetical protein-
GTF71_RS15255367941..368234+294WP_125460920.1hypothetical protein-
GTF71_RS15260368590..368685+96WP_001907607.1DUF645 family protein-
GTF71_RS15265368879..369196-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF71_RS15270369215..369457-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GTF71_RS15275369699..370208+510WP_000405987.1GNAT family N-acetyltransferase-
GTF71_RS15280370265..370918+654WP_000226874.1hypothetical protein-
GTF71_RS15285371228..371446+219WP_001917086.1DUF3709 domain-containing protein-
GTF71_RS15290371849..372082+234WP_032482776.1DUF3709 domain-containing protein-
GTF71_RS15295372507..372687+181Protein_369DUF645 family protein-
GTF71_RS15300372954..373241+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF71_RS15305373252..373569+318WP_001232701.1HigA family addiction module antidote protein-
GTF71_RS15310373566..373676+111WP_134814058.1DUF3265 domain-containing protein-
GTF71_RS15315373853..373978+126WP_001944767.1DUF645 family protein-
GTF71_RS15320373994..374032+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306926..439292132366
insideIntegron--312006..438916126910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145849 WP_001180243.1 NZ_CP047300:c369196-368879 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145849 NZ_CP062702:c3588891-3588514 [Escherichia coli O157:H7]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCTGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGTGAAACAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145849 WP_000557292.1 NZ_CP047300:c369457-369215 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145849 NZ_CP062702:c3589349-3588981 [Escherichia coli O157:H7]
GTGTCAGACACGCTCCATGAAACAAATCACCCCGACGGCAATAACAACAGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGTATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCAAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References