Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 415361..415994 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag A1552VC_RS16740 Protein ID WP_000843587.1
Coordinates 415361..415693 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A1552VC_RS16745 Protein ID WP_000071008.1
Coordinates 415680..415994 (+) Length 105 a.a.

Genomic Context

A1552VC_RS19970A1552VC_RS16670A1552VC_RS16675A1552VC_RS20140A1552VC_RS16690A1552VC_RS16695A1552VC_RS16700A1552VC_RS20145A1552VC_RS16705A1552VC_RS16720A1552VC_RS16725A1552VC_RS16740A1552VC_RS16745A1552VC_RS16750A1552VC_RS19895A1552VC_RS16760A1552VC_RS16765A1552VC_RS16770A1552VC_RS16775A1552VC_RS16780A1552VC_RS16785A1552VC_RS16790A1552VC_RS16755
Location: 410802..411005 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 411286..411459 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 411819..412088 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 412406..412577 (172 bp)
Type: Others
Protein ID: Protein_432
Location: 412786..413172 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 413374..413616 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 413787..414164 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 414221..414335 (115 bp)
Type: Others
Protein ID: Protein_436
Location: 414284..414565 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 414731..414844 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 414793..415020 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 415361..415693 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 415680..415994 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 416131..416565 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 416733..416888 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 418061..418367 (307 bp)
Type: Others
Protein ID: Protein_445
Location: 418504..419196 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 419196..419597 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 419567..419710 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419785..420198 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 420412..420663 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420653..420940 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 417013..417993 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A1552VC_RS19970410802..411005+204WP_001911745.1hypothetical protein-
A1552VC_RS16670411286..411459+174WP_001882305.1DUF3709 domain-containing protein-
A1552VC_RS16675411819..412088+270WP_001198131.1hypothetical protein-
A1552VC_RS20140412406..412577+172Protein_432DUF645 family protein-
A1552VC_RS16690412786..413172+387WP_000703163.1VOC family protein-
A1552VC_RS16695413374..413616+243WP_000107461.1hypothetical protein-
A1552VC_RS16700413787..414164+378WP_000411109.1hypothetical protein-
A1552VC_RS20145414221..414335+115Protein_436acetyltransferase-
A1552VC_RS16705414284..414565+282WP_001894453.1DUF1289 domain-containing protein-
A1552VC_RS16720414731..414844+114WP_001889158.1hypothetical protein-
A1552VC_RS16725414793..415020+228WP_001894457.1DUF1289 domain-containing protein-
A1552VC_RS16740415361..415693+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
A1552VC_RS16745415680..415994+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
A1552VC_RS16750416131..416565+435WP_000256036.1GNAT family N-acetyltransferase-
A1552VC_RS19895416733..416888+156WP_000751734.1hypothetical protein-
A1552VC_RS16755417013..417993-981WP_000019370.1IS5-like element ISVch5 family transposase-
A1552VC_RS16760418061..418367+307Protein_445CatB-related O-acetyltransferase-
A1552VC_RS16765418504..419196+693WP_001047169.1GNAT family N-acetyltransferase-
A1552VC_RS16770419196..419597+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
A1552VC_RS16775419567..419710+144WP_071908341.1DUF3265 domain-containing protein-
A1552VC_RS16780419785..420198+414WP_000049417.1VOC family protein-
A1552VC_RS16785420412..420663+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
A1552VC_RS16790420653..420940+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805
flankIS/Tn--417013..417993980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T104344 WP_000843587.1 NZ_CP028895:415361-415693 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T104344 NZ_CP028895:415361-415693 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT104344 WP_000071008.1 NZ_CP028895:415680-415994 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT104344 NZ_CP028895:415680-415994 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References