Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 415361..415994 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag A1552VC_RS16740 Protein ID WP_000843587.1
Coordinates 415361..415693 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A1552VC_RS16745 Protein ID WP_000071008.1
Coordinates 415680..415994 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1552VC_RS19970 410802..411005 + 204 WP_001911745.1 hypothetical protein -
A1552VC_RS16670 411286..411459 + 174 WP_001882305.1 DUF3709 domain-containing protein -
A1552VC_RS16675 411819..412088 + 270 WP_001198131.1 hypothetical protein -
A1552VC_RS20140 412406..412577 + 172 Protein_432 DUF645 family protein -
A1552VC_RS16690 412786..413172 + 387 WP_000703163.1 VOC family protein -
A1552VC_RS16695 413374..413616 + 243 WP_000107461.1 hypothetical protein -
A1552VC_RS16700 413787..414164 + 378 WP_000411109.1 hypothetical protein -
A1552VC_RS20145 414221..414335 + 115 Protein_436 acetyltransferase -
A1552VC_RS16705 414284..414565 + 282 WP_001894453.1 DUF1289 domain-containing protein -
A1552VC_RS16720 414731..414844 + 114 WP_001889158.1 hypothetical protein -
A1552VC_RS16725 414793..415020 + 228 WP_001894457.1 DUF1289 domain-containing protein -
A1552VC_RS16740 415361..415693 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A1552VC_RS16745 415680..415994 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
A1552VC_RS16750 416131..416565 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
A1552VC_RS19895 416733..416888 + 156 WP_000751734.1 hypothetical protein -
A1552VC_RS16755 417013..417993 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
A1552VC_RS16760 418061..418367 + 307 Protein_445 CatB-related O-acetyltransferase -
A1552VC_RS16765 418504..419196 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
A1552VC_RS16770 419196..419597 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
A1552VC_RS16775 419567..419710 + 144 WP_071908341.1 DUF3265 domain-containing protein -
A1552VC_RS16780 419785..420198 + 414 WP_000049417.1 VOC family protein -
A1552VC_RS16785 420412..420663 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A1552VC_RS16790 420653..420940 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805
flank IS/Tn - - 417013..417993 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T104344 WP_000843587.1 NZ_CP028895:415361-415693 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T104344 NZ_CP028895:415361-415693 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT104344 WP_000071008.1 NZ_CP028895:415680-415994 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT104344 NZ_CP028895:415680-415994 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References