Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 446184..446682 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag DG176_RS16715 Protein ID WP_000589156.1
Coordinates 446416..446682 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag DG176_RS16710 Protein ID WP_000643598.1
Coordinates 446184..446429 (-) Length 82 a.a.

Genomic Context

DG176_RS16650DG176_RS16665DG176_RS16670DG176_RS16675DG176_RS16680DG176_RS16685DG176_RS16690DG176_RS19830DG176_RS16705DG176_RS16710DG176_RS16715DG176_RS16725DG176_RS16730DG176_RS19835DG176_RS19840DG176_RS16750DG176_RS16755DG176_RS16760DG176_RS16765DG176_RS16770DG176_RS16775DG176_RS16780
Location: 441674..441853 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 442431..442541 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 442551..443249 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 443372..443998 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 444040..444132 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 444147..444620 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 444820..445002 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 445063..445191 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 445294..446088 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 446184..446429 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 446416..446682 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 446867..447529 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 447657..448124 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 448336..448374 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 448428..448571 (144 bp)
Type: Others
Protein ID: Protein_439
Location: 448946..449224 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 449476..449718 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 449810..449959 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 449932..450183 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 450378..450764 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 450754..450855 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 451055..451261 (207 bp)
Type: Others
Protein ID: Protein_446
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG176_RS16650441674..441853-180WP_001883058.1DUF645 family protein-
DG176_RS16665442431..442541-111WP_079857360.1DUF3265 domain-containing protein-
DG176_RS16670442551..443249-699WP_001890502.1hypothetical protein-
DG176_RS16675443372..443998-627WP_000365424.1LysE family translocator-
DG176_RS16680444040..444132-93WP_014378730.1DUF3265 domain-containing protein-
DG176_RS16685444147..444620-474WP_001161076.1GrpB family protein-
DG176_RS16690444820..445002-183WP_000923182.1DUF645 family protein-
DG176_RS19830445063..445191-129WP_071908338.1general secretion pathway protein GspI-
DG176_RS16705445294..446088-795WP_001911581.1hypothetical protein-
DG176_RS16710446184..446429-246WP_000643598.1hypothetical proteinAntitoxin
DG176_RS16715446416..446682-267WP_000589156.1BrnT family toxinToxin
DG176_RS16725446867..447529-663WP_000960654.1hypothetical protein-
DG176_RS16730447657..448124-468WP_001289288.1OsmC family protein-
DG176_RS19835448336..448374-39WP_082798268.1hypothetical protein-
DG176_RS19840448428..448571-144Protein_439DUF645 family protein-
DG176_RS16750448946..449224-279WP_000280324.1DUF3709 domain-containing protein-
DG176_RS16755449476..449718-243WP_000107461.1hypothetical protein-
DG176_RS16760449810..449959-150WP_071908333.1DUF3265 domain-containing protein-
DG176_RS16765449932..450183-252WP_001890111.1TIGR03643 family protein-
DG176_RS16770450378..450764-387WP_000703163.1VOC family protein-
DG176_RS16775450754..450855-102WP_001921603.1hypothetical protein-
DG176_RS16780451055..451261-207Protein_446DUF3709 domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-379325..47629796972
insideIntegroncatB9-379701..46950989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T294381 WP_000589156.1 NZ_LT992489:c446682-446416 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT294381 WP_000643598.1 NZ_LT992489:c446429-446184 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A271VME2

References