58271

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 427083..427611 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag ASZ81_RS16760 Protein ID WP_000221352.1
Coordinates 427083..427373 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag ASZ81_RS16765 Protein ID WP_000213183.1
Coordinates 427363..427611 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ81_RS20960 422640..422765 + 126 WP_001944767.1 DUF645 family protein -
ASZ81_RS20965 422781..422819 + 39 WP_106019119.1 hypothetical protein -
ASZ81_RS16730 423032..424036 + 1005 WP_000964925.1 LD-carboxypeptidase -
ASZ81_RS16735 424189..424635 + 447 WP_000128977.1 hypothetical protein -
ASZ81_RS16740 424755..425684 + 930 WP_000335802.1 hypothetical protein -
ASZ81_RS20635 425681..425791 + 111 WP_071917832.1 DUF3265 domain-containing protein -
ASZ81_RS16750 425819..426295 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
ASZ81_RS16755 426432..426947 + 516 WP_001201528.1 lipocalin family protein -
ASZ81_RS16760 427083..427373 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ81_RS16765 427363..427611 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ81_RS16775 428182..428835 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
ASZ81_RS16780 429107..429532 + 426 WP_000415748.1 hypothetical protein -
ASZ81_RS16785 429740..430135 + 396 WP_000649527.1 DUF3465 domain-containing protein -
ASZ81_RS16790 430286..430816 + 531 WP_000415563.1 hypothetical protein -
ASZ81_RS16795 430954..431454 + 501 WP_000789723.1 hypothetical protein -
ASZ81_RS16800 431610..432008 + 399 WP_001882293.1 hypothetical protein -
ASZ81_RS16805 432108..432572 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304741..463550 158809
inside Integron - - 309821..463174 153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T58271 WP_000221352.1 NZ_CP013306:c427373-427083 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T58271 NZ_CP013306:c427373-427083 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT58271 WP_000213183.1 NZ_CP013306:c427611-427363 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT58271 NZ_CP013306:c427611-427363 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References