Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 211834..212381 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag ASZ83_RS15545 Protein ID WP_000229317.1
Coordinates 212079..212381 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ83_RS15540 Protein ID WP_000861987.1
Coordinates 211834..212091 (+) Length 86 a.a.

Genomic Context

ASZ83_RS15490ASZ83_RS15500ASZ83_RS15515ASZ83_RS15520ASZ83_RS15525ASZ83_RS15530ASZ83_RS15535ASZ83_RS15540ASZ83_RS15545ASZ83_RS15550ASZ83_RS15560ASZ83_RS15565ASZ83_RS15570ASZ83_RS15575ASZ83_RS15585ASZ83_RS15590ASZ83_RS20230ASZ83_RS15505ASZ83_RS15510
Location: 206863..207318 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 207640..207792 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 208991..209659 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 209811..210098 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 210239..210610 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 210677..211102 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 211099..211632 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 211834..212091 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 212079..212381 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 212615..213532 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 213689..214078 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 214214..214423 (210 bp)
Type: Others
Protein ID: Protein_296
Location: 214542..214979 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 215043..215261 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 215436..216308 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 216458..217057 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 217114..217218 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 207994..208491 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 208488..208760 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ83_RS15490206863..207318+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ83_RS15500207640..207792+153WP_001884520.1DUF645 family protein-
ASZ83_RS15505207994..208491-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ83_RS15510208488..208760-273WP_000246253.1DUF1778 domain-containing protein-
ASZ83_RS15515208991..209659+669WP_000043871.1hypothetical protein-
ASZ83_RS15520209811..210098+288WP_000426470.1hypothetical protein-
ASZ83_RS15525210239..210610+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ83_RS15530210677..211102+426WP_001882332.1DUF1778 domain-containing protein-
ASZ83_RS15535211099..211632+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ83_RS15540211834..212091+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ83_RS15545212079..212381+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ83_RS15550212615..213532+918WP_000186333.1alpha/beta hydrolase-
ASZ83_RS15560213689..214078+390WP_001081302.1hypothetical protein-
ASZ83_RS15565214214..214423+210Protein_296GNAT family N-acetyltransferase-
ASZ83_RS15570214542..214979+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ83_RS15575215043..215261+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ83_RS15585215436..216308+873WP_000254716.1DUF3800 domain-containing protein-
ASZ83_RS15590216458..217057+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ83_RS20230217114..217218+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--87981..224211136230
insideIntegron--93061..221594128533
flankIS/Tn--214542..214979437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T58386 WP_000229317.1 NZ_CP013316:212079-212381 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58386 NZ_CP013316:212079-212381 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58386 WP_000861987.1 NZ_CP013316:211834-212091 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58386 NZ_CP013316:211834-212091 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References