Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 376810..377369 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ81_RS16235 Protein ID WP_000578476.1
Coordinates 376810..377088 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ81_RS16240 Protein ID WP_000381183.1
Coordinates 377085..377369 (-) Length 95 a.a.

Genomic Context

ASZ81_RS16190ASZ81_RS16195ASZ81_RS16200ASZ81_RS16205ASZ81_RS16210ASZ81_RS16215ASZ81_RS16220ASZ81_RS16225ASZ81_RS16230ASZ81_RS16250ASZ81_RS16255ASZ81_RS16270ASZ81_RS16275ASZ81_RS16280ASZ81_RS16285ASZ81_RS16290ASZ81_RS16295ASZ81_RS16235ASZ81_RS16240
Location: 371888..372394 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 372551..372937 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 373194..373397 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 373592..373843 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 373816..373965 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 374112..374537 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 374743..375366 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 375579..376058 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 376246..376659 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 377564..378079 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 378144..378740 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 379132..379314 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 379514..379987 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 380002..380094 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 380136..380762 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 380885..381583 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 381593..381703 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 376810..377088 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 377085..377369 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ81_RS16190371888..372394+507WP_000393074.1hypothetical protein-
ASZ81_RS16195372551..372937+387WP_000703163.1VOC family protein-
ASZ81_RS16200373194..373397+204WP_001911580.1hypothetical protein-
ASZ81_RS16205373592..373843+252WP_001890111.1TIGR03643 family protein-
ASZ81_RS16210373816..373965+150WP_071908333.1DUF3265 domain-containing protein-
ASZ81_RS16215374112..374537+426WP_000415750.1hypothetical protein-
ASZ81_RS16220374743..375366+624WP_000247070.1DUF1349 domain-containing protein-
ASZ81_RS16225375579..376058+480WP_000009888.1lecithin retinol acyltransferase family protein-
ASZ81_RS16230376246..376659+414WP_000049420.1VOC family protein-
ASZ81_RS16235376810..377088-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
ASZ81_RS16240377085..377369-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
ASZ81_RS16250377564..378079+516WP_001201520.1lipocalin family protein-
ASZ81_RS16255378144..378740+597WP_000255434.1hypothetical protein-
ASZ81_RS16270379132..379314+183WP_000923182.1DUF645 family protein-
ASZ81_RS16275379514..379987+474WP_001161076.1GrpB family protein-
ASZ81_RS16280380002..380094+93WP_014378730.1DUF3265 domain-containing protein-
ASZ81_RS16285380136..380762+627WP_000365424.1LysE family translocator-
ASZ81_RS16290380885..381583+699WP_001890502.1hypothetical protein-
ASZ81_RS16295381593..381703+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304741..463550158809
insideIntegron--309821..463174153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58267 WP_000578476.1 NZ_CP013306:c377088-376810 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58267 NZ_CP013306:c377088-376810 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58267 WP_000381183.1 NZ_CP013306:c377369-377085 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58267 NZ_CP013306:c377369-377085 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References