113807

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 194199..194758 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag EEL44_RS01260 Protein ID WP_000578476.1
Coordinates 194480..194758 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag EEL44_RS01255 Protein ID WP_000381183.1
Coordinates 194199..194483 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEL44_RS01210 189865..189975 - 111 WP_079857360.1 DUF3265 domain-containing protein -
EEL44_RS01215 189985..190683 - 699 WP_001890502.1 hypothetical protein -
EEL44_RS01220 190806..191432 - 627 WP_000365424.1 LysE family translocator -
EEL44_RS01225 191474..191566 - 93 WP_014378730.1 DUF3265 domain-containing protein -
EEL44_RS01230 191581..192054 - 474 WP_001161076.1 GrpB family protein -
EEL44_RS01235 192254..192436 - 183 WP_000923182.1 DUF645 family protein -
EEL44_RS01245 192828..193424 - 597 WP_000255434.1 hypothetical protein -
EEL44_RS01250 193489..194004 - 516 WP_001201520.1 lipocalin family protein -
EEL44_RS01255 194199..194483 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EEL44_RS01260 194480..194758 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EEL44_RS01270 194909..195322 - 414 WP_000049420.1 VOC family protein -
EEL44_RS01280 195510..195989 - 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
EEL44_RS01285 196202..196825 - 624 WP_000247070.1 DUF1349 domain-containing protein -
EEL44_RS01290 197031..197456 - 426 WP_000415750.1 hypothetical protein -
EEL44_RS01295 197603..197752 - 150 WP_071908333.1 DUF3265 domain-containing protein -
EEL44_RS01300 197725..197976 - 252 WP_001890111.1 TIGR03643 family protein -
EEL44_RS01305 198171..198374 - 204 WP_001911580.1 hypothetical protein -
EEL44_RS01310 198631..199017 - 387 WP_000703163.1 VOC family protein -
EEL44_RS01315 199174..199680 - 507 WP_000393074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 126763..233717 106954
inside Integron - - 127139..226875 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T113807 WP_000578476.1 NZ_CP033513:194480-194758 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T113807 NZ_CP033513:194480-194758 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT113807 WP_000381183.1 NZ_CP033513:194199-194483 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT113807 NZ_CP033513:194199-194483 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References