Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 194199..194758 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag EEL44_RS01260 Protein ID WP_000578476.1
Coordinates 194480..194758 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag EEL44_RS01255 Protein ID WP_000381183.1
Coordinates 194199..194483 (+) Length 95 a.a.

Genomic Context

EEL44_RS01255EEL44_RS01260EEL44_RS01210EEL44_RS01215EEL44_RS01220EEL44_RS01225EEL44_RS01230EEL44_RS01235EEL44_RS01245EEL44_RS01250EEL44_RS01270EEL44_RS01280EEL44_RS01285EEL44_RS01290EEL44_RS01295EEL44_RS01300EEL44_RS01305EEL44_RS01310EEL44_RS01315
Location: 194199..194483 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 194480..194758 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 189865..189975 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 189985..190683 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 190806..191432 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 191474..191566 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 191581..192054 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 192254..192436 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 192828..193424 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 193489..194004 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 194909..195322 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 195510..195989 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 196202..196825 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 197031..197456 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 197603..197752 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 197725..197976 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 198171..198374 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 198631..199017 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 199174..199680 (507 bp)
Type: Others
Protein ID: WP_000393074.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EEL44_RS01210189865..189975-111WP_079857360.1DUF3265 domain-containing protein-
EEL44_RS01215189985..190683-699WP_001890502.1hypothetical protein-
EEL44_RS01220190806..191432-627WP_000365424.1LysE family translocator-
EEL44_RS01225191474..191566-93WP_014378730.1DUF3265 domain-containing protein-
EEL44_RS01230191581..192054-474WP_001161076.1GrpB family protein-
EEL44_RS01235192254..192436-183WP_000923182.1DUF645 family protein-
EEL44_RS01245192828..193424-597WP_000255434.1hypothetical protein-
EEL44_RS01250193489..194004-516WP_001201520.1lipocalin family protein-
EEL44_RS01255194199..194483+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
EEL44_RS01260194480..194758+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
EEL44_RS01270194909..195322-414WP_000049420.1VOC family protein-
EEL44_RS01280195510..195989-480WP_000009888.1lecithin retinol acyltransferase family protein-
EEL44_RS01285196202..196825-624WP_000247070.1DUF1349 domain-containing protein-
EEL44_RS01290197031..197456-426WP_000415750.1hypothetical protein-
EEL44_RS01295197603..197752-150WP_071908333.1DUF3265 domain-containing protein-
EEL44_RS01300197725..197976-252WP_001890111.1TIGR03643 family protein-
EEL44_RS01305198171..198374-204WP_001911580.1hypothetical protein-
EEL44_RS01310198631..199017-387WP_000703163.1VOC family protein-
EEL44_RS01315199174..199680-507WP_000393074.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-126763..233717106954
insideIntegron--127139..22687599736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T113807 WP_000578476.1 NZ_CP033513:194480-194758 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T113807 NZ_CP033513:194480-194758 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT113807 WP_000381183.1 NZ_CP033513:194199-194483 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT113807 NZ_CP033513:194199-194483 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References