113797

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 136352..136899 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag EEL44_RS00650 Protein ID WP_000229317.1
Coordinates 136352..136654 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag EEL44_RS00655 Protein ID WP_000861987.1
Coordinates 136642..136899 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEL44_RS00610 131515..131619 - 105 WP_099607150.1 acetyltransferase -
EEL44_RS00615 131676..132275 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
EEL44_RS00620 132425..133297 - 873 WP_000254716.1 DUF3800 domain-containing protein -
EEL44_RS00625 133472..133690 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
EEL44_RS00630 133754..134191 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
EEL44_RS00635 134310..134519 - 210 Protein_118 GNAT family N-acetyltransferase -
EEL44_RS00640 134655..135044 - 390 WP_001081302.1 hypothetical protein -
EEL44_RS00645 135201..136118 - 918 WP_000186333.1 alpha/beta hydrolase -
EEL44_RS00650 136352..136654 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EEL44_RS00655 136642..136899 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EEL44_RS00665 137101..137634 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
EEL44_RS00670 137631..138056 - 426 WP_001882332.1 DUF1778 domain-containing protein -
EEL44_RS00675 138123..138494 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
EEL44_RS00680 138635..138922 - 288 WP_000426470.1 hypothetical protein -
EEL44_RS00685 139074..139742 - 669 WP_000043871.1 hypothetical protein -
EEL44_RS00690 139973..140245 + 273 WP_000246253.1 DUF1778 domain-containing protein -
EEL44_RS00695 140242..140739 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
EEL44_RS00705 140941..141093 - 153 WP_001884520.1 DUF645 family protein -
EEL44_RS00710 141415..141870 - 456 WP_001245327.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 126763..233717 106954
inside Integron - - 127139..226875 99736
flank IS/Tn - - 133754..134191 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T113797 WP_000229317.1 NZ_CP033513:c136654-136352 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T113797 NZ_CP033513:c136654-136352 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT113797 WP_000861987.1 NZ_CP033513:c136899-136642 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT113797 NZ_CP033513:c136899-136642 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References