Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 136352..136899 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag EEL44_RS00650 Protein ID WP_000229317.1
Coordinates 136352..136654 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag EEL44_RS00655 Protein ID WP_000861987.1
Coordinates 136642..136899 (-) Length 86 a.a.

Genomic Context

EEL44_RS00690EEL44_RS00695EEL44_RS00610EEL44_RS00615EEL44_RS00620EEL44_RS00625EEL44_RS00630EEL44_RS00635EEL44_RS00640EEL44_RS00645EEL44_RS00650EEL44_RS00655EEL44_RS00665EEL44_RS00670EEL44_RS00675EEL44_RS00680EEL44_RS00685EEL44_RS00705EEL44_RS00710
Location: 139973..140245 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 140242..140739 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 131515..131619 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 131676..132275 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 132425..133297 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 133472..133690 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 133754..134191 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 134310..134519 (210 bp)
Type: Others
Protein ID: Protein_118
Location: 134655..135044 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 135201..136118 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 136352..136654 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 136642..136899 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 137101..137634 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 137631..138056 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 138123..138494 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 138635..138922 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 139074..139742 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 140941..141093 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 141415..141870 (456 bp)
Type: Others
Protein ID: WP_001245327.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EEL44_RS00610131515..131619-105WP_099607150.1acetyltransferase-
EEL44_RS00615131676..132275-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
EEL44_RS00620132425..133297-873WP_000254716.1DUF3800 domain-containing protein-
EEL44_RS00625133472..133690-219WP_071908318.1GNAT family N-acetyltransferase-
EEL44_RS00630133754..134191-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
EEL44_RS00635134310..134519-210Protein_118GNAT family N-acetyltransferase-
EEL44_RS00640134655..135044-390WP_001081302.1hypothetical protein-
EEL44_RS00645135201..136118-918WP_000186333.1alpha/beta hydrolase-
EEL44_RS00650136352..136654-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EEL44_RS00655136642..136899-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
EEL44_RS00665137101..137634-534WP_000118351.1GNAT family N-acetyltransferase-
EEL44_RS00670137631..138056-426WP_001882332.1DUF1778 domain-containing protein-
EEL44_RS00675138123..138494-372WP_001164080.1nucleotide pyrophosphohydrolase-
EEL44_RS00680138635..138922-288WP_000426470.1hypothetical protein-
EEL44_RS00685139074..139742-669WP_000043871.1hypothetical protein-
EEL44_RS00690139973..140245+273WP_000246253.1DUF1778 domain-containing protein-
EEL44_RS00695140242..140739+498WP_000982260.1GNAT family N-acetyltransferase-
EEL44_RS00705140941..141093-153WP_001884520.1DUF645 family protein-
EEL44_RS00710141415..141870-456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-126763..233717106954
insideIntegron--127139..22687599736
flankIS/Tn--133754..134191437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T113797 WP_000229317.1 NZ_CP033513:c136654-136352 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T113797 NZ_CP033513:c136654-136352 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT113797 WP_000861987.1 NZ_CP033513:c136899-136642 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT113797 NZ_CP033513:c136899-136642 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References