145892

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 400283..400811 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag GTF74_RS15865 Protein ID WP_000221352.1
Coordinates 400283..400573 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag GTF74_RS15870 Protein ID WP_000213183.1
Coordinates 400563..400811 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF74_RS15830 395840..396044 + 205 Protein_412 DUF645 family protein -
GTF74_RS15835 396232..397236 + 1005 WP_000964925.1 LD-carboxypeptidase -
GTF74_RS15840 397389..397835 + 447 WP_000128977.1 hypothetical protein -
GTF74_RS15845 397955..398884 + 930 WP_000335802.1 hypothetical protein -
GTF74_RS15850 398881..398991 + 111 WP_071917832.1 DUF3265 domain-containing protein -
GTF74_RS15855 399019..399495 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
GTF74_RS15860 399632..400147 + 516 WP_001201528.1 lipocalin family protein -
GTF74_RS15865 400283..400573 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF74_RS15870 400563..400811 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF74_RS15875 401382..402035 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
GTF74_RS15880 402307..402732 + 426 WP_000415748.1 hypothetical protein -
GTF74_RS15885 402940..403335 + 396 WP_000649527.1 DUF3465 domain-containing protein -
GTF74_RS15890 403486..404016 + 531 WP_000415563.1 hypothetical protein -
GTF74_RS15895 404154..404654 + 501 WP_000789723.1 hypothetical protein -
GTF74_RS15900 404810..405208 + 399 WP_001882293.1 hypothetical protein -
GTF74_RS15905 405308..405772 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 307032..436751 129719
inside Integron - - 312112..436375 124263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T145892 WP_000221352.1 NZ_CP047304:c400573-400283 [Vibrio cholerae O1 biovar El Tor]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T145892 NZ_CP062707:c26352-26092 [Escherichia coli O157:H7]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTATTTTTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT145892 WP_000213183.1 NZ_CP047304:c400811-400563 [Vibrio cholerae O1 biovar El Tor]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT145892 NZ_CP062707:c26102-25860 [Escherichia coli O157:H7]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATATCTTCAGCTTTTAGCTGGGGAACATCCTGAATACGTCCTGCGCAAAAGGGATAAACCTAAATGTAGTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References