88989

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 326689..327229 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag VCA1552_RS15785 Protein ID WP_000277238.1
Coordinates 326689..326958 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag VCA1552_RS15790 Protein ID WP_001258569.1
Coordinates 326951..327229 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCA1552_RS15715 321693..321935 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VCA1552_RS15720 322179..322565 + 387 WP_001015867.1 NUDIX hydrolase -
VCA1552_RS15725 322622..322735 + 114 WP_001900214.1 hypothetical protein -
VCA1552_RS15730 322684..322965 + 282 WP_001894429.1 DUF1289 domain-containing protein -
VCA1552_RS15745 323223..323759 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
VCA1552_RS15750 323896..324411 + 516 WP_001201509.1 lipocalin family protein -
VCA1552_RS15755 324561..325058 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
VCA1552_RS15760 325055..325327 - 273 WP_000246253.1 DUF1778 domain-containing protein -
VCA1552_RS15765 325720..325845 + 126 WP_001900195.1 DUF645 family protein -
VCA1552_RS15770 325861..325899 + 39 WP_106019118.1 hypothetical protein -
VCA1552_RS15780 326095..326541 + 447 WP_000006157.1 hypothetical protein -
VCA1552_RS15785 326689..326958 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
VCA1552_RS15790 326951..327229 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VCA1552_RS15800 327515..327793 + 279 WP_001921601.1 DUF3709 domain-containing protein -
VCA1552_RS15805 328045..328251 + 207 Protein_290 DUF3709 domain-containing protein -
VCA1552_RS15810 328451..328552 + 102 WP_001921603.1 hypothetical protein -
VCA1552_RS15815 328542..328928 + 387 WP_000703163.1 VOC family protein -
VCA1552_RS15820 329123..329374 + 252 WP_001890111.1 TIGR03643 family protein -
VCA1552_RS15825 329347..329496 + 150 WP_071908333.1 DUF3265 domain-containing protein -
VCA1552_RS15830 329588..329830 + 243 WP_000107461.1 hypothetical protein -
VCA1552_RS15835 330082..330360 + 279 WP_000280324.1 DUF3709 domain-containing protein -
VCA1552_RS19985 330735..330878 + 144 Protein_297 DUF645 family protein -
VCA1552_RS19990 330932..330970 + 39 WP_082798268.1 hypothetical protein -
VCA1552_RS15850 331182..331649 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304717..433978 129261
inside Integron - - 309797..433602 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T88989 WP_000277238.1 NZ_CP024868:c326958-326689 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T88989 NZ_CP024868:c326958-326689 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT88989 WP_001258569.1 NZ_CP024868:c327229-326951 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT88989 NZ_CP024868:c327229-326951 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References