198978

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 323554..324132 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag J9265_RS15155 Protein ID WP_001180243.1
Coordinates 323554..323871 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag J9265_RS15160 Protein ID WP_000557292.1
Coordinates 323890..324132 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9265_RS15125 (J9265_15125) 319078..319260 + 183 WP_000923340.1 DUF645 family protein -
J9265_RS18995 319380..319442 + 63 Protein_273 acetyltransferase -
J9265_RS15130 (J9265_15130) 319614..319796 + 183 WP_000923153.1 DUF645 family protein -
J9265_RS15135 (J9265_15135) 319991..320668 + 678 WP_000254617.1 HNH endonuclease signature motif containing protein -
J9265_RS15140 (J9265_15140) 320830..322038 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
J9265_RS15145 (J9265_15145) 322200..322904 + 705 WP_000087610.1 HNH endonuclease -
J9265_RS15150 (J9265_15150) 323062..323400 + 339 WP_000713853.1 hypothetical protein -
J9265_RS15155 (J9265_15155) 323554..323871 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9265_RS15160 (J9265_15160) 323890..324132 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J9265_RS15165 (J9265_15165) 324376..324762 + 387 WP_001015867.1 NUDIX hydrolase -
J9265_RS15170 (J9265_15170) 324819..324932 + 114 WP_001900214.1 hypothetical protein -
J9265_RS15175 (J9265_15175) 324941..325162 + 222 WP_032467793.1 DUF1289 domain-containing protein -
J9265_RS15180 (J9265_15180) 325420..325956 + 537 WP_000469482.1 GNAT family protein -
J9265_RS15185 (J9265_15185) 326147..326608 + 462 WP_001903091.1 lipocalin family protein -
J9265_RS19000 326673..326741 + 69 Protein_286 acetyltransferase -
J9265_RS15190 (J9265_15190) 326758..327255 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
J9265_RS15195 (J9265_15195) 327252..327524 - 273 WP_000246253.1 DUF1778 domain-containing protein -
J9265_RS15200 (J9265_15200) 327917..328042 + 126 WP_001900195.1 DUF645 family protein -
J9265_RS15210 (J9265_15210) 328292..328738 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T198978 WP_001180243.1 NZ_CP072848:c323871-323554 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T198978 NZ_CP097079:c2599848-2598526 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTACTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT198978 WP_000557292.1 NZ_CP072848:c324132-323890 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT198978 NZ_CP097079:c2600114-2599848 [Klebsiella pneumoniae]
ATGAATTCCCCCCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGATGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References