Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 325779..326545 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GTF75_RS15330 Protein ID WP_000982260.1
Coordinates 325779..326276 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GTF75_RS15335 Protein ID WP_000246253.1
Coordinates 326273..326545 (-) Length 91 a.a.

Genomic Context

GTF75_RS15280GTF75_RS15285GTF75_RS15300GTF75_RS15305GTF75_RS15310GTF75_RS15320GTF75_RS15325GTF75_RS15340GTF75_RS15345GTF75_RS15350GTF75_RS15365GTF75_RS15370GTF75_RS15375GTF75_RS15380GTF75_RS15385GTF75_RS15390GTF75_RS15395GTF75_RS15290GTF75_RS15295GTF75_RS15315GTF75_RS15330GTF75_RS15335GTF75_RS15355GTF75_RS15360
Location: 321221..321925 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 322083..322421 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 323397..323783 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 323840..323953 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 323902..324183 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 324441..324977 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 325114..325629 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 326938..327063 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 327079..327117 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 327313..327759 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 328733..329011 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 329263..329469 (207 bp)
Type: Others
Protein ID: Protein_293
Location: 329669..329770 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 329760..330146 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 330341..330592 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 330565..330714 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 330806..331048 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 322575..322892 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 322911..323153 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 324159..324317 (159 bp)
Type: Others
Protein ID: WP_001886450.1
Location: 325779..326276 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 326273..326545 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 327907..328176 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 328169..328447 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF75_RS15280321221..321925+705WP_000087610.1HNH endonuclease-
GTF75_RS15285322083..322421+339WP_000713853.1hypothetical protein-
GTF75_RS15290322575..322892-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF75_RS15295322911..323153-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF75_RS15300323397..323783+387WP_001015867.1NUDIX hydrolase-
GTF75_RS15305323840..323953+114WP_001900214.1hypothetical protein-
GTF75_RS15310323902..324183+282WP_001894429.1DUF1289 domain-containing protein-
GTF75_RS15315324159..324317-159WP_001886450.1DUF1196 family protein-
GTF75_RS15320324441..324977+537WP_000469482.1GNAT family N-acetyltransferase-
GTF75_RS15325325114..325629+516WP_001201509.1lipocalin family protein-
GTF75_RS15330325779..326276-498WP_000982260.1GNAT family N-acetyltransferaseToxin
GTF75_RS15335326273..326545-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
GTF75_RS15340326938..327063+126WP_001900195.1DUF645 family protein-
GTF75_RS15345327079..327117+39WP_106019118.1hypothetical protein-
GTF75_RS15350327313..327759+447WP_000006157.1hypothetical protein-
GTF75_RS15355327907..328176-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
GTF75_RS15360328169..328447-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
GTF75_RS15365328733..329011+279WP_001921601.1DUF3709 domain-containing protein-
GTF75_RS15370329263..329469+207Protein_293DUF3709 domain-containing protein-
GTF75_RS15375329669..329770+102WP_001921603.1hypothetical protein-
GTF75_RS15380329760..330146+387WP_000703163.1VOC family protein-
GTF75_RS15385330341..330592+252WP_001890111.1TIGR03643 family protein-
GTF75_RS15390330565..330714+150WP_071908333.1DUF3265 domain-containing protein-
GTF75_RS15395330806..331048+243WP_000107461.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305935..411136105201
insideIntegron--311015..41076099745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145865 WP_000982260.1 NZ_CP047302:c326276-325779 [Vibrio cholerae O1 biovar El Tor]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145865 NZ_CP062705:432920-433894 [Escherichia coli O157:H7]
GTGGGGCGTGCCGGTCGCGGTATCGATTCTGCTGTTGGCATACTGCTTTGCGGCAGTGAAGACCGTGCTATTCATAAATT
CTTCCGTGAAAGCGCCTTTCCTGCGGAGGCGCAAATTCATGAAATACTCAACGTACTTAGCGTGAATGACGGTCTTACCT
TACGAGGCATTGAACAACGGACGAATCTCCGTTATGGGCAAATAGAAAAAGCACTGAAATTATTGGTAGCTGAAAATCCA
TCGCCTGTGGTGTATACCGAGAAATTATGGCGCAGAACAATTGTCAGTTTTTCTCCTGACCATGAACGAATTAACCATTT
GATGAATCAGAGAAAAAGTGAGCTGGCAGACGTTGAAAGCTATATCACGACCAAGGAGTGCAAAATGCAATTTCTGCGCC
GCGCACTCGATGAGCCAGGTGCCGAACATTGTGGTAAATGTAGCAGTTGTCTTCAGCATCCGTTGTTGTCGCCCGACATT
GATAGCGGCTTACTCCATGCGGCAAACTTATTTATTAAACACGCTGACCTGTCATTAAATCTCAATAAACAGGTGGCAGC
TGGGGCTTTTACGCAATACGGATTTAAAGGGAACTTGCCTGCGAGTTTACAAGGATCTACGGGGCGAATCCTTTCTCGTT
GGGGATATTCCGGGTGGGGAAAGCAGGTAGCACAGGAGAAAAAAACGGGGCGATTCAGTGATGAACTGGTGGAGGCATGT
GCGGAAATGGTTCGCCAACGCTGGAATCCGCATCCTGAACCAACCTGGGTATGCTGCGTTCCTTCATTAAAGCACCTCGA
CCTGGTTCCTGATTTTGAAAGCACCTCGACCTGGTTCCTGATTTTGCCCGGCGACTGGCGGCGAAACTTGGCTTACCTTT
TATTGATGCCATTGAAAAAGTCGTGGACAATCCACCGCAGAAAATGCAGCAAAACCGTTTCCACCAGTGTCAAAATCTCG
ACGGGGCGTTTGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145865 WP_000246253.1 NZ_CP047302:c326545-326273 [Vibrio cholerae O1 biovar El Tor]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145865 NZ_CP062705:433953-435248 [Escherichia coli O157:H7]
ATGGACGCTGACAGTTCTAACAGCACTGTTACGCCAGGCAGGTTGCCCGACGGTTTATCCTCTTGCCCTTGCTTCTACCT
CGGTAAAAAATTGATGAATCTTTCAGCCAATGCACAAGCAACTCTCCTGCTAACCAGCGATTTTTCTCGCGCGGCGGCGA
GTAAGTATAAACCTCTTAGTAATAGTGAATGGGGGAAGTTTGCATTATGGCTGAAGCACCAACGTATCAGTCCCGCCGAG
CTTCTGGTGCCGCAACCGCAAGAGAAACTTACAGGCTGGAGCGATCCGCGTATTTCTCAGGAGCGTATTCTTGGCTTGCT
GGCGCGTGGTCATAGTCTGGCGTTGGCGGTAGATAAGTGGCAACGCGCCGGTTTATGGATCTTAACCCGCGGAGATGCTG
ATTATCCCGTTCGCTTGAAAAACCGATTGCGAACGGATGCACCTCCCGTTTTATTTGGCTGCGGGAATAAAGCATTACTG
CAAGCGGAAGGTATGGCGATTGTTGGCTCGCGAGATGCTCCGACTGACGATTTGCGCTATACCCAACAACTGGCCGCGAA
ACTGGCCCAACAGGGGATTTGCGTTATCTCTGGTGGTGCGCGAGGTATTGATGAATGTGCAATGGCGTCGGCACTGGAGG
CCGGGGGAACTGCCGTTGGCGTATTAGCTGATAGCTTGTTAAAAACGAGTACGTTAGTGAAATGGCGTGAAGGGCTTATA
GCAGGCAACCTGGTGTTGATTTCGCCGTTTTACCCAGAGGTACGTTTCACCGTCGGCAATGCGATGGCGCGAAATAAATA
TATTTATTGCCTTGCTGAAAGCGCAATGGTTGTACGTGCGGGAATGACCGGTGGAACGATAACCGGGGCGATGGAGGCAT
TAAAACATCAGTGGCTGCCTGTGCAGGTTAAACCAAATCAGGATATGCAATCAGCCAATTCACGATTAGTAGAAAATGGG
GCGTCATGGAGTGCTGAACAGGCTGAGAATGTGACGATCAGACTGCCAGACGTTCCTGGGCTGATGTATGACAGAGCACT
CCGTAACGCTCAACCAGAACTGTTTTCGCTGCATGAAGATGACGCAAATTACGCAGTAATGCCCGCGTATACGCCTGTCG
ATTTTTATCAACTCTTTGTGGCGGAACTGGCGATCCTTGCAAAGGAATCGATAAGTATTGAAAGGCTGGCGTCTTGTACT
GGTTTAACCATCGAACAAATTAGTGTGTGGCTGAACCGCGCAGAAGAAGAGGGAAGGGTTATCCGATTGGGCGAAGGTCA
TTATCAGTTCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

Loading, please wait
Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References