38684

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 300718..301296 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag K6J80_RS15570 Protein ID WP_001180243.1
Coordinates 300979..301296 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag K6J80_RS15565 Protein ID WP_000557292.1
Coordinates 300718..300960 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J80_RS15515 296112..296558 - 447 WP_000006157.1 hypothetical protein -
K6J80_RS15525 296808..296933 - 126 WP_001900195.1 DUF645 family protein -
K6J80_RS15530 297326..297598 + 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J80_RS15535 297595..298092 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
K6J80_RS19100 298109..298177 - 69 Protein_355 acetyltransferase -
K6J80_RS15540 298242..298703 - 462 WP_001903091.1 lipocalin family protein -
K6J80_RS15545 298894..299430 - 537 WP_000469482.1 GNAT family protein -
K6J80_RS15550 299688..299909 - 222 WP_032467793.1 DUF1289 domain-containing protein -
K6J80_RS15555 299918..300031 - 114 WP_001900214.1 hypothetical protein -
K6J80_RS15560 300088..300474 - 387 WP_001015867.1 NUDIX hydrolase -
K6J80_RS15565 300718..300960 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J80_RS15570 300979..301296 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J80_RS15575 301450..301788 - 339 WP_000713853.1 hypothetical protein -
K6J80_RS15580 301946..302650 - 705 WP_000087610.1 HNH endonuclease -
K6J80_RS15585 302812..304020 - 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
K6J80_RS15590 304182..304859 - 678 WP_000254617.1 HNH endonuclease signature motif containing protein -
K6J80_RS15595 305054..305236 - 183 WP_000923153.1 DUF645 family protein -
K6J80_RS19105 305408..305470 - 63 Protein_368 acetyltransferase -
K6J80_RS15600 305590..305772 - 183 WP_000923340.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 213119..319686 106567
inside Integron - - 213119..312856 99737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T38684 WP_001180243.1 NZ_AP024554:300979-301296 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T38684 NZ_AP024554:300979-301296 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT38684 WP_000557292.1 NZ_AP024554:300718-300960 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT38684 NZ_AP024554:300718-300960 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References