Detailed information of TA system TA092514

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 419352..420118
• Replicon: chromosome
• Accession: NZ_CP025937
• Organism: Vibrio cholerae strain A1552

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9K2P7
• Locus tag: C1H56_RS16770
• Protein ID: WP_000982260.1
• Coordinates: 419352..419849 (-)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9K2J6
• Locus tag: C1H56_RS16775
• Protein ID: WP_000246253.1
• Coordinates: 419846..420118 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1H56_RS16720	415214..415486	+	273	Protein_444	CatB-related O-acetyltransferase	-
C1H56_RS16725	415657..416349	+	693	WP_001047169.1	GNAT family N-acetyltransferase	-
C1H56_RS16730	416349..416750	+	402	WP_000351248.1	type II toxin-antitoxin system death-on-curing family toxin	-
C1H56_RS16735	416720..416863	+	144	WP_071908341.1	DUF3265 domain-containing protein	-
C1H56_RS16740	416938..417351	+	414	WP_000049417.1	VOC family protein	-
C1H56_RS16745	417565..417816	+	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
C1H56_RS16750	417806..418093	+	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
C1H56_RS16755	418221..418676	+	456	WP_001245327.1	GNAT family N-acetyltransferase	-
C1H56_RS16760	418998..419150	+	153	WP_001884520.1	DUF645 family protein	-
C1H56_RS16770	419352..419849	-	498	WP_000982260.1	GNAT family N-acetyltransferase	Toxin
C1H56_RS16775	419846..420118	-	273	WP_000246253.1	DUF1778 domain-containing protein	Antitoxin
C1H56_RS16780	420349..421017	+	669	WP_000043871.1	hypothetical protein	-
C1H56_RS16785	421169..421456	+	288	WP_000426470.1	hypothetical protein	-
C1H56_RS16790	421597..421968	+	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
C1H56_RS20010	422035..422460	+	426	WP_001882332.1	DUF1778 domain-containing protein	-
C1H56_RS16800	422457..422990	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-
C1H56_RS16810	423192..423449	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
C1H56_RS16815	423437..423739	+	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
C1H56_RS16820	423973..424890	+	918	WP_000186333.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	304067..433328	129261
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0	inside	Integron	catB9	-	309147..432952	123805
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000174, TA000175, TA000176, TA010030 416601..417581 0.001	flank	IS/Tn	-	-	414166..415146	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-86)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18527.18 Da
• Isoelectric Point: 8.7753

>T92514 WP_000982260.1 NZ_CP025937:c419849-419352 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Nucleotide

• Length: 498 bp

>T92514 NZ_CP025937:c419849-419352 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9683.22 Da
• Isoelectric Point: 6.2988

>AT92514 WP_000246253.1 NZ_CP025937:c420118-419846 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Nucleotide

• Length: 273 bp

>AT92514 NZ_CP025937:c420118-419846 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Structures

Toxin

• AlphaFold DB: A0A0Q0KGB1

Antitoxin

• AlphaFold DB: A0A0F2IC79