Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 419352..420118 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag C1H56_RS16770 Protein ID WP_000982260.1
Coordinates 419352..419849 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag C1H56_RS16775 Protein ID WP_000246253.1
Coordinates 419846..420118 (-) Length 91 a.a.

Genomic Context

C1H56_RS16720C1H56_RS16725C1H56_RS16730C1H56_RS16735C1H56_RS16740C1H56_RS16745C1H56_RS16750C1H56_RS16755C1H56_RS16760C1H56_RS16780C1H56_RS16785C1H56_RS16790C1H56_RS20010C1H56_RS16800C1H56_RS16810C1H56_RS16815C1H56_RS16820C1H56_RS16770C1H56_RS16775
Location: 415214..415486 (273 bp)
Type: Others
Protein ID: Protein_444
Location: 415657..416349 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 416349..416750 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 416720..416863 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 416938..417351 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 417565..417816 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 417806..418093 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 418221..418676 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 418998..419150 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 420349..421017 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421169..421456 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 421597..421968 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 422035..422460 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 422457..422990 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 423192..423449 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 423437..423739 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 423973..424890 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 419352..419849 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 419846..420118 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1H56_RS16720415214..415486+273Protein_444CatB-related O-acetyltransferase-
C1H56_RS16725415657..416349+693WP_001047169.1GNAT family N-acetyltransferase-
C1H56_RS16730416349..416750+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
C1H56_RS16735416720..416863+144WP_071908341.1DUF3265 domain-containing protein-
C1H56_RS16740416938..417351+414WP_000049417.1VOC family protein-
C1H56_RS16745417565..417816+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
C1H56_RS16750417806..418093+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
C1H56_RS16755418221..418676+456WP_001245327.1GNAT family N-acetyltransferase-
C1H56_RS16760418998..419150+153WP_001884520.1DUF645 family protein-
C1H56_RS16770419352..419849-498WP_000982260.1GNAT family N-acetyltransferaseToxin
C1H56_RS16775419846..420118-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
C1H56_RS16780420349..421017+669WP_000043871.1hypothetical protein-
C1H56_RS16785421169..421456+288WP_000426470.1hypothetical protein-
C1H56_RS16790421597..421968+372WP_001164080.1nucleotide pyrophosphohydrolase-
C1H56_RS20010422035..422460+426WP_001882332.1DUF1778 domain-containing protein-
C1H56_RS16800422457..422990+534WP_000118351.1GNAT family N-acetyltransferase-
C1H56_RS16810423192..423449+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
C1H56_RS16815423437..423739+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
C1H56_RS16820423973..424890+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304067..433328129261
insideIntegroncatB9-309147..432952123805
flankIS/Tn--414166..415146980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T92514 WP_000982260.1 NZ_CP025937:c419849-419352 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T92514 NZ_CP025937:c419849-419352 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT92514 WP_000246253.1 NZ_CP025937:c420118-419846 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT92514 NZ_CP025937:c420118-419846 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References