92519

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 430600..431159 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag C1H56_RS16885 Protein ID WP_000578476.1
Coordinates 430600..430878 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag C1H56_RS16890 Protein ID WP_000381183.1
Coordinates 430875..431159 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H56_RS16835 425900..426337 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
C1H56_RS16840 426401..426619 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
C1H56_RS16845 426794..427666 + 873 WP_000254716.1 DUF3800 domain-containing protein -
C1H56_RS16850 427816..428415 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
C1H56_RS16855 428472..428576 + 105 WP_099607150.1 acetyltransferase -
C1H56_RS16860 428607..428876 + 270 WP_001114075.1 DUF4160 domain-containing protein -
C1H56_RS16865 428870..429391 + 522 WP_000921691.1 DUF2442 domain-containing protein -
C1H56_RS16870 429690..429815 + 126 WP_001905700.1 DUF645 family protein -
C1H56_RS16880 430066..430461 + 396 WP_001000867.1 hypothetical protein -
C1H56_RS16885 430600..430878 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
C1H56_RS16890 430875..431159 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C1H56_RS16895 431353..431868 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
C1H56_RS16905 432052..432465 + 414 WP_000049420.1 VOC family protein -
C1H56_RS16915 433020..434197 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304067..433328 129261
inside Integron catB9 - 309147..432952 123805
flank IS/Tn - - 425900..426337 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T92519 WP_000578476.1 NZ_CP025937:c430878-430600 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T92519 NZ_CP025937:c430878-430600 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT92519 WP_000381183.1 NZ_CP025937:c431159-430875 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT92519 NZ_CP025937:c431159-430875 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References