Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 430600..431159 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag C1H56_RS16885 Protein ID WP_000578476.1
Coordinates 430600..430878 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag C1H56_RS16890 Protein ID WP_000381183.1
Coordinates 430875..431159 (-) Length 95 a.a.

Genomic Context

C1H56_RS16835C1H56_RS16840C1H56_RS16845C1H56_RS16850C1H56_RS16855C1H56_RS16860C1H56_RS16865C1H56_RS16870C1H56_RS16880C1H56_RS16895C1H56_RS16905C1H56_RS16915C1H56_RS16885C1H56_RS16890
Location: 425900..426337 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 426401..426619 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 426794..427666 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 427816..428415 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 428472..428576 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 428607..428876 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 428870..429391 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 429690..429815 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 430066..430461 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 431353..431868 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 432052..432465 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 433020..434197 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 430600..430878 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 430875..431159 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1H56_RS16835425900..426337+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
C1H56_RS16840426401..426619+219WP_071908318.1GNAT family N-acetyltransferase-
C1H56_RS16845426794..427666+873WP_000254716.1DUF3800 domain-containing protein-
C1H56_RS16850427816..428415+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
C1H56_RS16855428472..428576+105WP_099607150.1acetyltransferase-
C1H56_RS16860428607..428876+270WP_001114075.1DUF4160 domain-containing protein-
C1H56_RS16865428870..429391+522WP_000921691.1DUF2442 domain-containing protein-
C1H56_RS16870429690..429815+126WP_001905700.1DUF645 family protein-
C1H56_RS16880430066..430461+396WP_001000867.1hypothetical protein-
C1H56_RS16885430600..430878-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
C1H56_RS16890430875..431159-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
C1H56_RS16895431353..431868+516WP_000343779.1GNAT family N-acetyltransferase-
C1H56_RS16905432052..432465+414WP_000049420.1VOC family protein-
C1H56_RS16915433020..434197+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304067..433328129261
insideIntegroncatB9-309147..432952123805
flankIS/Tn--425900..426337437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T92519 WP_000578476.1 NZ_CP025937:c430878-430600 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T92519 NZ_CP025937:c430878-430600 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT92519 WP_000381183.1 NZ_CP025937:c431159-430875 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT92519 NZ_CP025937:c431159-430875 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References