104247

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 324993..325571 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag N16961_RS15495 Protein ID WP_001180243.1
Coordinates 324993..325310 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag N16961_RS15500 Protein ID WP_000557292.1
Coordinates 325329..325571 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N16961_RS15455 320517..320699 + 183 WP_000923340.1 DUF645 family protein -
N16961_RS15460 321053..321235 + 183 WP_000923153.1 DUF645 family protein -
N16961_RS15470 321430..322107 + 678 WP_000254617.1 HNH endonuclease -
N16961_RS15475 322269..323477 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
N16961_RS15480 323639..324343 + 705 WP_000087610.1 HNH endonuclease -
N16961_RS15485 324501..324839 + 339 WP_000713853.1 hypothetical protein -
N16961_RS15495 324993..325310 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N16961_RS15500 325329..325571 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N16961_RS15505 325815..326201 + 387 WP_001015867.1 NUDIX hydrolase -
N16961_RS15510 326258..326371 + 114 WP_001900214.1 hypothetical protein -
N16961_RS15515 326320..326601 + 282 WP_001894429.1 DUF1289 domain-containing protein -
N16961_RS15530 326859..327395 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
N16961_RS15535 327532..328047 + 516 WP_001201509.1 lipocalin family protein -
N16961_RS15540 328197..328694 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
N16961_RS15545 328691..328963 - 273 WP_000246253.1 DUF1778 domain-containing protein -
N16961_RS15550 329356..329481 + 126 WP_001900195.1 DUF645 family protein -
N16961_RS15555 329497..329535 + 39 WP_106019118.1 hypothetical protein -
N16961_RS15565 329731..330177 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306977..438073 131096
inside Integron - - 312057..437697 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T104247 WP_001180243.1 NZ_CP028828:c325310-324993 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T104247 NZ_CP028828:c325310-324993 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT104247 WP_000557292.1 NZ_CP028828:c325571-325329 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT104247 NZ_CP028828:c325571-325329 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References