Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 324993..325571 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag N16961_RS15495 Protein ID WP_001180243.1
Coordinates 324993..325310 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag N16961_RS15500 Protein ID WP_000557292.1
Coordinates 325329..325571 (-) Length 81 a.a.

Genomic Context

N16961_RS15455N16961_RS15460N16961_RS15470N16961_RS15475N16961_RS15480N16961_RS15485N16961_RS15505N16961_RS15510N16961_RS15515N16961_RS15530N16961_RS15535N16961_RS15550N16961_RS15555N16961_RS15565N16961_RS15495N16961_RS15500N16961_RS15540N16961_RS15545
Location: 320517..320699 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 321053..321235 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 321430..322107 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 322269..323477 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 323639..324343 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 324501..324839 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 325815..326201 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 326258..326371 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 326320..326601 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 326859..327395 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 327532..328047 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 329356..329481 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 329497..329535 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 329731..330177 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 324993..325310 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 325329..325571 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 328197..328694 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 328691..328963 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N16961_RS15455320517..320699+183WP_000923340.1DUF645 family protein-
N16961_RS15460321053..321235+183WP_000923153.1DUF645 family protein-
N16961_RS15470321430..322107+678WP_000254617.1HNH endonuclease-
N16961_RS15475322269..323477+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
N16961_RS15480323639..324343+705WP_000087610.1HNH endonuclease-
N16961_RS15485324501..324839+339WP_000713853.1hypothetical protein-
N16961_RS15495324993..325310-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N16961_RS15500325329..325571-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
N16961_RS15505325815..326201+387WP_001015867.1NUDIX hydrolase-
N16961_RS15510326258..326371+114WP_001900214.1hypothetical protein-
N16961_RS15515326320..326601+282WP_001894429.1DUF1289 domain-containing protein-
N16961_RS15530326859..327395+537WP_000469482.1GNAT family N-acetyltransferase-
N16961_RS15535327532..328047+516WP_001201509.1lipocalin family protein-
N16961_RS15540328197..328694-498WP_000982260.1GNAT family N-acetyltransferase-
N16961_RS15545328691..328963-273WP_000246253.1DUF1778 domain-containing protein-
N16961_RS15550329356..329481+126WP_001900195.1DUF645 family protein-
N16961_RS15555329497..329535+39WP_106019118.1hypothetical protein-
N16961_RS15565329731..330177+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306977..438073131096
insideIntegron--312057..437697125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T104247 WP_001180243.1 NZ_CP028828:c325310-324993 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T104247 NZ_CP028828:c325310-324993 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT104247 WP_000557292.1 NZ_CP028828:c325571-325329 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT104247 NZ_CP028828:c325571-325329 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References