145809

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 365752..366330 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GTF72_RS15555 Protein ID WP_001180243.1
Coordinates 365752..366069 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GTF72_RS15560 Protein ID WP_000557292.1
Coordinates 366088..366330 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF72_RS15510 360982..361338 + 357 WP_001094969.1 hypothetical protein -
GTF72_RS15515 361641..361822 + 182 Protein_351 DUF645 family protein -
GTF72_RS15520 361999..362394 + 396 WP_000046953.1 hypothetical protein -
GTF72_RS15525 362538..363074 + 537 WP_000644491.1 nucleotidyltransferase family protein -
GTF72_RS15530 363371..363550 + 180 WP_001883039.1 DUF645 family protein -
GTF72_RS15535 363746..364171 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
GTF72_RS15540 364320..364667 + 348 WP_000933409.1 hypothetical protein -
GTF72_RS15545 364814..365107 + 294 WP_125460920.1 hypothetical protein -
GTF72_RS15550 365463..365558 + 96 WP_001907607.1 DUF645 family protein -
GTF72_RS15555 365752..366069 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF72_RS15560 366088..366330 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF72_RS15565 366572..367081 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
GTF72_RS15570 367138..367791 + 654 WP_000226874.1 hypothetical protein -
GTF72_RS15575 368101..368319 + 219 WP_001917086.1 DUF3709 domain-containing protein -
GTF72_RS15580 368722..368955 + 234 WP_032482776.1 DUF3709 domain-containing protein -
GTF72_RS15585 369380..369560 + 181 Protein_365 DUF645 family protein -
GTF72_RS15590 369827..370114 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTF72_RS15595 370125..370442 + 318 WP_001232701.1 HigA family addiction module antidote protein -
GTF72_RS15600 370439..370549 + 111 WP_134814058.1 DUF3265 domain-containing protein -
GTF72_RS15605 370726..370851 + 126 WP_001944767.1 DUF645 family protein -
GTF72_RS15610 370867..370905 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306905..436165 129260
inside Integron - - 311985..435789 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145809 WP_001180243.1 NZ_CP047296:c366069-365752 [Vibrio cholerae C6706]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145809 NZ_CP062700:934723-935130 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145809 WP_000557292.1 NZ_CP047296:c366330-366088 [Vibrio cholerae C6706]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145809 NZ_CP062700:934476-934742 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References