211916

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 977987..978565 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag K1T75_RS18165 Protein ID WP_001180243.1
Coordinates 978248..978565 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag K1T75_RS18160 Protein ID WP_000557292.1
Coordinates 977987..978229 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS18890 973387..973503 - 117 WP_001889170.1 hypothetical protein -
K1T75_RS18120 973466..973591 - 126 WP_001944767.1 DUF645 family protein -
K1T75_RS18895 973619..973729 - 111 Protein_877 acetyltransferase -
K1T75_RS18900 973768..973878 - 111 WP_134814058.1 DUF3265 domain-containing protein -
K1T75_RS18125 973875..974192 - 318 WP_001232701.1 HigA family addiction module antitoxin -
K1T75_RS18130 974203..974490 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
K1T75_RS18905 974531..974644 - 114 WP_001894955.1 hypothetical protein -
K1T75_RS18135 974757..974937 - 181 Protein_882 DUF645 family protein -
K1T75_RS18140 975362..975595 - 234 WP_032482776.1 DUF3709 domain-containing protein -
K1T75_RS18910 975616..975809 - 194 Protein_884 hypothetical protein -
K1T75_RS18145 975998..976216 - 219 WP_001917086.1 DUF3709 domain-containing protein -
K1T75_RS18915 976228..976437 - 210 WP_001900246.1 DUF3709 domain-containing protein -
K1T75_RS18150 976526..977179 - 654 WP_000226874.1 hypothetical protein -
K1T75_RS18155 977236..977745 - 510 WP_000405987.1 GNAT family N-acetyltransferase -
K1T75_RS18160 977987..978229 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K1T75_RS18165 978248..978565 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1T75_RS18920 978759..978911 - 153 Protein_891 DUF645 family protein -
K1T75_RS18925 978972..979147 - 176 Protein_892 acetyltransferase -
K1T75_RS18175 979210..979503 - 294 WP_125460920.1 hypothetical protein -
K1T75_RS18180 979650..979997 - 348 WP_000933409.1 hypothetical protein -
K1T75_RS18185 980146..980571 - 426 WP_000403014.1 GNAT family N-acetyltransferase -
K1T75_RS18930 980730..980840 - 111 WP_223804330.1 Tfp pilus assembly protein -
K1T75_RS18935 980830..980892 - 63 Protein_897 DUF645 family protein -
K1T75_RS18195 981243..981779 - 537 WP_000644491.1 nucleotidyltransferase family protein -
K1T75_RS18200 981923..982279 - 357 WP_001094970.1 DUF6404 family protein -
K1T75_RS18205 982495..982614 - 120 WP_001900954.1 DUF645 family protein -
K1T75_RS18940 982737..982880 - 144 Protein_901 acetyltransferase -
K1T75_RS18210 982979..983335 - 357 WP_001094969.1 DUF6404 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T211916 WP_001180243.1 NZ_CP080466:978248-978565 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T211916 NZ_CP106842:4487-4822 [Paenalcaligenes faecalis]
GTGGGAATAGTCAGGCGAGGTGACATTGTGAGTATTGCAACGCAGGGCGATTTTGGAAAACCACGTCCTGCGCTTGTAAT
CCAATCGGATTTATTTTCGGCACACCCGAGTGTTAGCGTATTGCCAATTACCTCTTTTTTGATCGATGCGCCGTTGTTAC
GTATTACTCTTGAGCCCAATGAGTTCAACGGTTTGAAGAAAAAATCACAAGTGATGATTGATAAAATAATAACGGTGGTA
CGTGAAAAAGTGGGTGGTCAAATTGGCTCGCTGGATTTTGCCACGATGCAAGAAATCGATCGTTGTTTAGCTGTGTTTTT
AGGTATTGTGCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT211916 WP_000557292.1 NZ_CP080466:977987-978229 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT211916 NZ_CP106842:4275-4496 [Paenalcaligenes faecalis]
ATGCGACCTGATACGCCAAACAGTACTAGCCGAGTACAAAAACATCGTGCGAAATTACGTAAAGCGGGGATGAAGCCCGT
GCAAATTTGGGTACCTGATACCACAAGCAAAGCGTTTATTGCTGAGTGTGAGCGTCAAAGCCGCCTAATTGCTCAATCAG
ATGATGTGATGACTCATGGTTTGTTGGACGAAGCACTGATTGAGGTAGACGGGTGGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References