Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 468310..469094 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ87_RS16570 Protein ID WP_001114075.1
Coordinates 468310..468579 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID C3LUY7
Locus tag ASZ87_RS16575 Protein ID WP_000921692.1
Coordinates 468573..469094 (+) Length 174 a.a.

Genomic Context

ASZ87_RS16525ASZ87_RS20990ASZ87_RS21065ASZ87_RS20560ASZ87_RS16550ASZ87_RS16560ASZ87_RS16570ASZ87_RS16575ASZ87_RS20580ASZ87_RS16580ASZ87_RS16585ASZ87_RS20585ASZ87_RS16590ASZ87_RS16600ASZ87_RS16605ASZ87_RS16610ASZ87_RS16615ASZ87_RS16510ASZ87_RS16515
Location: 464677..464754 (78 bp)
Type: Others
Protein ID: WP_071908337.1
Location: 464758..464784 (27 bp)
Type: Others
Protein ID: Protein_414
Location: 465370..465513 (144 bp)
Type: Others
Protein ID: WP_001900215.1
Location: 465607..465786 (180 bp)
Type: Others
Protein ID: Protein_416
Location: 466004..466432 (429 bp)
Type: Others
Protein ID: WP_000620002.1
Location: 467020..467502 (483 bp)
Type: Others
Protein ID: WP_000422940.1
Location: 468310..468579 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 468573..469094 (522 bp)
Type: Antitoxin
Protein ID: WP_000921692.1
Location: 469151..469264 (114 bp)
Type: Others
Protein ID: WP_001894981.1
Location: 469233..470069 (837 bp)
Type: Others
Protein ID: WP_000242986.1
Location: 470234..470872 (639 bp)
Type: Others
Protein ID: WP_000230118.1
Location: 470962..471122 (161 bp)
Type: Others
Protein ID: Protein_424
Location: 471143..471364 (222 bp)
Type: Others
Protein ID: WP_012705854.1
Location: 471684..472004 (321 bp)
Type: Others
Protein ID: WP_001909340.1
Location: 472001..472534 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 472772..473050 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 473451..473675 (225 bp)
Type: Others
Protein ID: WP_001894423.1
Location: 463720..464019 (300 bp)
Type: Others
Protein ID: WP_000802136.1
Location: 464016..464258 (243 bp)
Type: Others
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS16510463720..464019-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ87_RS16515464016..464258-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxin-
ASZ87_RS16525464677..464754+78WP_071908337.1DUF645 family protein-
ASZ87_RS20990464758..464784+27Protein_414hypothetical protein-
ASZ87_RS21065465370..465513+144WP_001900215.1hypothetical protein-
ASZ87_RS20560465607..465786+180Protein_416DUF645 family protein-
ASZ87_RS16550466004..466432+429WP_000620002.1N-acetyltransferase-
ASZ87_RS16560467020..467502+483WP_000422940.1GNAT family N-acetyltransferase-
ASZ87_RS16570468310..468579+270WP_001114075.1DUF4160 domain-containing proteinToxin
ASZ87_RS16575468573..469094+522WP_000921692.1DUF2442 domain-containing proteinAntitoxin
ASZ87_RS20580469151..469264+114WP_001894981.1hypothetical protein-
ASZ87_RS16580469233..470069+837WP_000242986.1hypothetical protein-
ASZ87_RS16585470234..470872+639WP_000230118.1HD domain-containing protein-
ASZ87_RS20585470962..471122+161Protein_424DUF3709 domain-containing protein-
ASZ87_RS16590471143..471364+222WP_012705854.1DUF3709 domain-containing protein-
ASZ87_RS16600471684..472004+321WP_001909340.1DUF1778 domain-containing protein-
ASZ87_RS16605472001..472534+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ87_RS16610472772..473050+279WP_000280324.1DUF3709 domain-containing protein-
ASZ87_RS16615473451..473675+225WP_001894423.1DUF3709 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58304 WP_001114075.1 NZ_CP013310:468310-468579 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58304 NZ_CP013310:468310-468579 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19439.04 Da        Isoelectric Point: 6.7342

>AT58304 WP_000921692.1 NZ_CP013310:468573-469094 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT58304 NZ_CP013310:468573-469094 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBC3LUY7

References