Detailed information of TA system TA058304

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 468310..469094
• Replicon: chromosome
• Accession: NZ_CP013310
• Organism: Vibrio cholerae strain E1162

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: ASZ87_RS16570
• Protein ID: WP_001114075.1
• Coordinates: 468310..468579 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: C3LUY7
• Locus tag: ASZ87_RS16575
• Protein ID: WP_000921692.1
• Coordinates: 468573..469094 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ87_RS16510	463720..464019	-	300	WP_000802136.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ASZ87_RS16515	464016..464258	-	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	-
ASZ87_RS16525	464677..464754	+	78	WP_071908337.1	DUF645 family protein	-
ASZ87_RS20990	464758..464784	+	27	Protein_414	hypothetical protein	-
ASZ87_RS21065	465370..465513	+	144	WP_001900215.1	hypothetical protein	-
ASZ87_RS20560	465607..465786	+	180	Protein_416	DUF645 family protein	-
ASZ87_RS16550	466004..466432	+	429	WP_000620002.1	N-acetyltransferase	-
ASZ87_RS16560	467020..467502	+	483	WP_000422940.1	GNAT family N-acetyltransferase	-
ASZ87_RS16570	468310..468579	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
ASZ87_RS16575	468573..469094	+	522	WP_000921692.1	DUF2442 domain-containing protein	Antitoxin
ASZ87_RS20580	469151..469264	+	114	WP_001894981.1	hypothetical protein	-
ASZ87_RS16580	469233..470069	+	837	WP_000242986.1	hypothetical protein	-
ASZ87_RS16585	470234..470872	+	639	WP_000230118.1	HD domain-containing protein	-
ASZ87_RS20585	470962..471122	+	161	Protein_424	DUF3709 domain-containing protein	-
ASZ87_RS16590	471143..471364	+	222	WP_012705854.1	DUF3709 domain-containing protein	-
ASZ87_RS16600	471684..472004	+	321	WP_001909340.1	DUF1778 domain-containing protein	-
ASZ87_RS16605	472001..472534	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-
ASZ87_RS16610	472772..473050	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
ASZ87_RS16615	473451..473675	+	225	WP_001894423.1	DUF3709 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	435534..596659	161125
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.005	inside	Integron	-	-	440614..596283	155669

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T58304 WP_001114075.1 NZ_CP013310:468310-468579 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T58304 NZ_CP013310:468310-468579 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19439.04 Da
• Isoelectric Point: 6.7342

>AT58304 WP_000921692.1 NZ_CP013310:468573-469094 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT58304 NZ_CP013310:468573-469094 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Structures

Toxin

• AlphaFold DB: A0A086SLD6

Antitoxin

• AlphaFold DB: C3LUY7