Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 327932..328472 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag GQX72_RS15255 Protein ID WP_000277238.1
Coordinates 327932..328201 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag GQX72_RS15260 Protein ID WP_001258569.1
Coordinates 328194..328472 (-) Length 93 a.a.

Genomic Context

GQX72_RS15200GQX72_RS15205GQX72_RS15210GQX72_RS15220GQX72_RS15225GQX72_RS15240GQX72_RS15250GQX72_RS15265GQX72_RS15270GQX72_RS15275GQX72_RS15280GQX72_RS15285GQX72_RS15290GQX72_RS15295GQX72_RS15300GQX72_RS19015GQX72_RS19020GQX72_RS15310GQX72_RS15195GQX72_RS15230GQX72_RS15235GQX72_RS15255GQX72_RS15260
Location: 323422..323808 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 323865..323978 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 323927..324208 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 324466..325002 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 325139..325654 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 326963..327088 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 327338..327784 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 328758..329036 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 329288..329494 (207 bp)
Type: Others
Protein ID: Protein_290
Location: 329694..329795 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 329785..330171 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 330366..330617 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 330590..330739 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 330831..331073 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 331325..331603 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 331978..332121 (144 bp)
Type: Others
Protein ID: Protein_297
Location: 332175..332213 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 332425..332892 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 322936..323178 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 325804..326301 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 326298..326570 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 327932..328201 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 328194..328472 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GQX72_RS15195322936..323178-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GQX72_RS15200323422..323808+387WP_001015867.1NUDIX hydrolase-
GQX72_RS15205323865..323978+114WP_001900214.1hypothetical protein-
GQX72_RS15210323927..324208+282WP_001894429.1DUF1289 domain-containing protein-
GQX72_RS15220324466..325002+537WP_000469482.1GNAT family N-acetyltransferase-
GQX72_RS15225325139..325654+516WP_001201509.1lipocalin family protein-
GQX72_RS15230325804..326301-498WP_000982260.1GNAT family N-acetyltransferase-
GQX72_RS15235326298..326570-273WP_000246253.1DUF1778 domain-containing protein-
GQX72_RS15240326963..327088+126WP_001905700.1DUF645 family protein-
GQX72_RS15250327338..327784+447WP_000006157.1hypothetical protein-
GQX72_RS15255327932..328201-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
GQX72_RS15260328194..328472-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
GQX72_RS15265328758..329036+279WP_001921601.1DUF3709 domain-containing protein-
GQX72_RS15270329288..329494+207Protein_290DUF3709 domain-containing protein-
GQX72_RS15275329694..329795+102WP_001921603.1hypothetical protein-
GQX72_RS15280329785..330171+387WP_000703163.1VOC family protein-
GQX72_RS15285330366..330617+252WP_001890111.1TIGR03643 family protein-
GQX72_RS15290330590..330739+150WP_071908333.1DUF3265 domain-containing protein-
GQX72_RS15295330831..331073+243WP_000107461.1hypothetical protein-
GQX72_RS15300331325..331603+279WP_000280324.1DUF3709 domain-containing protein-
GQX72_RS19015331978..332121+144Protein_297DUF645 family protein-
GQX72_RS19020332175..332213+39WP_082798268.1hypothetical protein-
GQX72_RS15310332425..332892+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305960..411159105199
insideIntegron--311040..41078399743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T145394 WP_000277238.1 NZ_CP047060:c328201-327932 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T145394 NZ_CP062372:c1868336-1868184 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT145394 WP_001258569.1 NZ_CP047060:c328472-328194 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT145394 NZ_CP062372:c1868960-1868361 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGGGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References