Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 402824..403352 | Replicon | chromosome |
| Accession | NZ_CP047300 | ||
| Organism | Vibrio cholerae O1 biovar El Tor strain P27459 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | H9L4R3 |
| Locus tag | GTF71_RS15560 | Protein ID | WP_000221352.1 |
| Coordinates | 402824..403114 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | H9L4T4 |
| Locus tag | GTF71_RS15565 | Protein ID | WP_000213183.1 |
| Coordinates | 403104..403352 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GTF71_RS15525 | 398381..398585 | + | 205 | Protein_415 | DUF645 family protein | - |
| GTF71_RS15530 | 398773..399777 | + | 1005 | WP_000964925.1 | LD-carboxypeptidase | - |
| GTF71_RS15535 | 399930..400376 | + | 447 | WP_000128977.1 | hypothetical protein | - |
| GTF71_RS15540 | 400496..401425 | + | 930 | WP_000335802.1 | hypothetical protein | - |
| GTF71_RS15545 | 401422..401532 | + | 111 | WP_071917832.1 | DUF3265 domain-containing protein | - |
| GTF71_RS15550 | 401560..402036 | + | 477 | WP_001047180.1 | GNAT family N-acetyltransferase | - |
| GTF71_RS15555 | 402173..402688 | + | 516 | WP_001201528.1 | lipocalin family protein | - |
| GTF71_RS15560 | 402824..403114 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GTF71_RS15565 | 403104..403352 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GTF71_RS15570 | 403923..404576 | + | 654 | WP_000036957.1 | site-specific DNA-methyltransferase | - |
| GTF71_RS15575 | 404848..405273 | + | 426 | WP_000415748.1 | hypothetical protein | - |
| GTF71_RS15580 | 405481..405876 | + | 396 | WP_000649527.1 | DUF3465 domain-containing protein | - |
| GTF71_RS15585 | 406027..406557 | + | 531 | WP_000415563.1 | hypothetical protein | - |
| GTF71_RS15590 | 406695..407195 | + | 501 | WP_000789723.1 | hypothetical protein | - |
| GTF71_RS15595 | 407351..407749 | + | 399 | WP_001882293.1 | hypothetical protein | - |
| GTF71_RS15600 | 407849..408313 | - | 465 | WP_000140244.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 306926..439292 | 132366 | |
| inside | Integron | - | - | 312006..438916 | 126910 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11247.23 Da Isoelectric Point: 10.4678
>T145852 WP_000221352.1 NZ_CP047300:c403114-402824 [Vibrio cholerae O1 biovar El Tor]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T145852 NZ_CP062702:c4409542-4409144 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8937.28 Da Isoelectric Point: 4.1079
>AT145852 WP_000213183.1 NZ_CP047300:c403352-403104 [Vibrio cholerae O1 biovar El Tor]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT145852 NZ_CP062702:c4409838-4409545 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | H9L4R3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A366A3W8 |