Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 379078..379711 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag LVJ30_RS15820 Protein ID WP_000843587.1
Coordinates 379078..379410 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LVJ30_RS15825 Protein ID WP_000071008.1
Coordinates 379397..379711 (+) Length 105 a.a.

Genomic Context

LVJ30_RS15760LVJ30_RS15765LVJ30_RS15770LVJ30_RS15775LVJ30_RS15780LVJ30_RS15785LVJ30_RS15790LVJ30_RS15795LVJ30_RS15800LVJ30_RS15805LVJ30_RS15810LVJ30_RS15815LVJ30_RS15820LVJ30_RS15825LVJ30_RS15830LVJ30_RS15835LVJ30_RS15845LVJ30_RS15850LVJ30_RS15855LVJ30_RS15860LVJ30_RS15865LVJ30_RS15870LVJ30_RS15875LVJ30_RS15880LVJ30_RS15840
Location: 374313..374378 (66 bp)
Type: Others
Protein ID: Protein_385
Location: 374519..374722 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 374979..375176 (198 bp)
Type: Others
Protein ID: WP_001894451.1
Location: 375536..375805 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 376141..376294 (154 bp)
Type: Others
Protein ID: Protein_389
Location: 376503..376889 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 376974..377333 (360 bp)
Type: Others
Protein ID: WP_226979446.1
Location: 377504..377881 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 377938..378052 (115 bp)
Type: Others
Protein ID: Protein_393
Location: 378061..378282 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 378448..378561 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 378510..378737 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 379078..379410 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 379397..379711 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 379848..380282 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 380450..380605 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 381778..382084 (307 bp)
Type: Others
Protein ID: Protein_402
Location: 382221..382619 (399 bp)
Type: Others
Protein ID: Protein_403
Location: 382743..382913 (171 bp)
Type: Others
Protein ID: WP_001080654.1
Location: 382913..383314 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 383317..383427 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 383502..383915 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 384129..384380 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 384370..384657 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 380730..381710 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LVJ30_RS15760374313..374378+66Protein_385acetyltransferase-
LVJ30_RS15765 (LVJ30_15765)374519..374722+204WP_001911745.1hypothetical protein-
LVJ30_RS15770 (LVJ30_15770)374979..375176+198WP_001894451.1DUF3709 domain-containing protein-
LVJ30_RS15775 (LVJ30_15775)375536..375805+270WP_001198131.1hypothetical protein-
LVJ30_RS15780 (LVJ30_15780)376141..376294+154Protein_389DUF645 family protein-
LVJ30_RS15785 (LVJ30_15785)376503..376889+387WP_000703163.1VOC family protein-
LVJ30_RS15790 (LVJ30_15790)376974..377333+360WP_226979446.1pullulanase-
LVJ30_RS15795 (LVJ30_15795)377504..377881+378WP_000411109.1hypothetical protein-
LVJ30_RS15800 (LVJ30_15800)377938..378052+115Protein_393acetyltransferase-
LVJ30_RS15805 (LVJ30_15805)378061..378282+222WP_032468461.1DUF1289 domain-containing protein-
LVJ30_RS15810 (LVJ30_15810)378448..378561+114WP_001889158.1hypothetical protein-
LVJ30_RS15815 (LVJ30_15815)378510..378737+228WP_001894457.1DUF1289 domain-containing protein-
LVJ30_RS15820 (LVJ30_15820)379078..379410+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LVJ30_RS15825 (LVJ30_15825)379397..379711+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
LVJ30_RS15830 (LVJ30_15830)379848..380282+435WP_000256036.1GNAT family N-acetyltransferase-
LVJ30_RS15835 (LVJ30_15835)380450..380605+156WP_000751734.1hypothetical protein-
LVJ30_RS15840 (LVJ30_15840)380730..381710-981WP_000019370.1IS5-like element ISVch5 family transposase-
LVJ30_RS15845 (LVJ30_15845)381778..382084+307Protein_402CatB-related O-acetyltransferase-
LVJ30_RS15850 (LVJ30_15850)382221..382619+399Protein_403GNAT family N-acetyltransferase-
LVJ30_RS15855 (LVJ30_15855)382743..382913+171WP_001080654.1hypothetical protein-
LVJ30_RS15860 (LVJ30_15860)382913..383314+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
LVJ30_RS15865 (LVJ30_15865)383317..383427+111WP_082798255.1DUF3265 domain-containing protein-
LVJ30_RS15870 (LVJ30_15870)383502..383915+414WP_000049417.1VOC family protein-
LVJ30_RS15875 (LVJ30_15875)384129..384380+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
LVJ30_RS15880 (LVJ30_15880)384370..384657+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791
flankIS/Tn--380730..381710980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T230523 WP_000843587.1 NZ_CP090379:379078-379410 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T230523 NZ_CP124917:35449-35724 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT230523 WP_000071008.1 NZ_CP090379:379397-379711 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT230523 NZ_CP124917:35190-35456 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References